Practical use of apomorphine infusion in Parkinson's disease: lessons from the TOLEDO study and clinical experience

Tove Henriksen, Regina Katzenschlager, Roongroj Bhidayasiri, Harry Staines, Donna Lockhart, Andrew Lees

6 Citationer (Scopus)

Abstract

Subcutaneous apomorphine infusion is a device-aided therapy for Parkinson's disease that can be considered when motor fluctuations become persistent and are no longer adequately controlled by oral/transdermal medication. Apomorphine infusion is less invasive than enteral levodopa, deep brain stimulation or focused ultrasound, and is often indicated even when neurosurgical approaches are contraindicated. This article aims to provide practical guidance for doctors and nurses initiating and treating patients with apomorphine infusion, and is based on both trial data and clinical experience from movement disorders specialists. A post hoc analysis of data from the TOLEDO randomized clinical trial of apomorphine infusion was conducted along with an analysis of 'real world' experience from 13 movement disorders specialists using a questionnaire that focused on starting patients on apomorphine infusion. Practical guidelines for starting treatment with apomorphine infusion are provided taking into consideration the regional disparities in healthcare. Apomorphine infusion is straightforward to administer but to be successful it requires concordance from the patient and family, and clinical support from an experienced team of doctors and nurses, particularly in the early months of treatment.

OriginalsprogEngelsk
TidsskriftJournal of neural transmission (Vienna, Austria : 1996)
Vol/bind130
Udgave nummer11
Sider (fra-til)1475-1484
Antal sider10
ISSN0300-9564
DOI
StatusUdgivet - nov. 2023

Fingeraftryk

Dyk ned i forskningsemnerne om 'Practical use of apomorphine infusion in Parkinson's disease: lessons from the TOLEDO study and clinical experience'. Sammen danner de et unikt fingeraftryk.

Citationsformater