Præimplantationsgenetisk testning

Kristine Løssl, Janne Gasseholm Bentzen, Morten Rønn Petersen, Laura Sønderberg Roos, Kristín Rós Kjartansdóttir, Marie Louise Grøndahl, Bettina Troest, Christian Liebst Frisk Toft, Inge Søkilde Pedersen, Tue Diemer, Hans Jakob Ingerslev

3 Citationer (Scopus)

Abstract

Preimplantation genetic testing (PGT) for known familial monogenetic disease (PGT-M) or structural chromosomal rearrangements (PGT-SR) has evolved into a well-established alternative to prenatal diagnosis. PGT significantly reduces the risk of a pregnancy with an affected foetus. Screening for aneuploidy (PGT-A) used as an add-on to standard IVF treatment of infertile couples is widely used internationally, although its benefit is highly debated. PGT combines genetic counselling and testing with assisted reproductive technology including ovarian stimulation, egg retrieval, and embryo biopsy, as discussed in this review.

Bidragets oversatte titelPreimplantation genetic testing
OriginalsprogDansk
ArtikelnummerV04210378
TidsskriftUgeskrift for Laeger
Vol/bind183
Udgave nummer48
Sider (fra-til)V04210378
ISSN0041-5782
StatusUdgivet - 29 nov. 2021

Emneord

  • Aneuploidy
  • Female
  • Fertilization in Vitro
  • Genetic Testing
  • Humans
  • Pregnancy
  • Preimplantation Diagnosis
  • Reproductive Techniques, Assisted

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