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PPARs and the development of Type 1 Diabetes

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Intestinal permeability in type 1 diabetes: An updated comprehensive overview

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Antibiotic treatment during early childhood and risk of type 1 diabetes in children: A national birth cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Insulin Independence in Newly Diagnosed Type 1 Diabetes Patient following Fenofibrate Treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Fenofibrate increases very-long-chain sphingolipids and improves blood glucose homeostasis in NOD mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.

OriginalsprogEngelsk
Artikelnummer6198628
TidsskriftPPAR Research
Vol/bind2020
Sider (fra-til)6198628
DOI
StatusUdgivet - 2020

ID: 59203949