TY - JOUR
T1 - PPARs and the development of Type 1 Diabetes
AU - Holm, Laurits Juulskov
AU - Mønsted, Mia Øgaard
AU - Haupt-Jorgensen, Martin
AU - Buschard, Karsten Stig
N1 - Copyright © 2020 Laurits J. Holm et al.
PY - 2020
Y1 - 2020
N2 - Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.
AB - Peroxisome proliferator-activated receptors (PPARs) are a family of transcription factors with a key role in glucose and lipid metabolism. PPARs are expressed in many cell types including pancreatic beta cells and immune cells, where they regulate insulin secretion and T cell differentiation, respectively. Moreover, various PPAR agonists prevent diabetes in the non-obese diabetic (NOD) mouse model of type 1 diabetes. PPARs are thus of interest in type 1 diabetes (T1D) as they represent a novel approach targeting both the pancreas and the immune system. In this review, we examine the role of PPARs in immune responses and beta cell biology and their potential as targets for treatment of T1D.
UR - http://www.scopus.com/inward/record.url?scp=85078142160&partnerID=8YFLogxK
U2 - 10.1155/2020/6198628
DO - 10.1155/2020/6198628
M3 - Review
C2 - 32395123
VL - 2020
SP - 6198628
JO - PPAR Research
JF - PPAR Research
M1 - 6198628
ER -