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PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Rasmus Koefoed Petersen
  • Signe Benzon Larsen
  • Ditte Marie Jensen
  • Jane Christensen
  • Anja Olsen
  • Steffen Loft
  • Christine Nellemann
  • Kim Overvad
  • Karsten Kristiansen
  • Anne Tjønneland
  • Ulla Vogel
Vis graf over relationer

Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPARγ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPARγ and the PPARγ-PGC-1α complex was inhibited by ethanol. PPARγ 12Ala-mediated transcription activation was not enhanced by PGC-1α, resulting in allele-specific transcription activation by the PPARγ 12Pro-PGC-1α complex. Our results suggest that PPARγ and PGC-1α activity is an important determinant of alcohol related breast cancer.

OriginalsprogEngelsk
TidsskriftCancer Letters
Vol/bind315
Udgave nummer1
Sider (fra-til)59-68
Antal sider10
ISSN0304-3835
DOI
StatusUdgivet - 1 feb. 2012

ID: 55535199