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PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

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Harvard

Blond, MB, Schnurr, TM, Rosenkilde, M, Quist, JS, Gram, AS, Reichkendler, MH, Auerbach, PL, Nordby, P, Skovgaard, LT, Ribel-Madsen, R, Justesen, JM, Kilpeläinen, TO, Ploug, T, Stallknecht, BM & Hansen, T 2019, 'PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training', Physiological genomics, bind 51, nr. 6, s. 254-260. https://doi.org/10.1152/physiolgenomics.00101.2018

APA

Blond, M. B., Schnurr, T. M., Rosenkilde, M., Quist, J. S., Gram, A. S., Reichkendler, M. H., Auerbach, P. L., Nordby, P., Skovgaard, L. T., Ribel-Madsen, R., Justesen, J. M., Kilpeläinen, T. O., Ploug, T., Stallknecht, B. M., & Hansen, T. (2019). PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. Physiological genomics, 51(6), 254-260. https://doi.org/10.1152/physiolgenomics.00101.2018

CBE

Blond MB, Schnurr TM, Rosenkilde M, Quist JS, Gram AS, Reichkendler MH, Auerbach PL, Nordby P, Skovgaard LT, Ribel-Madsen R, Justesen JM, Kilpeläinen TO, Ploug T, Stallknecht BM, Hansen T. 2019. PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. Physiological genomics. 51(6):254-260. https://doi.org/10.1152/physiolgenomics.00101.2018

MLA

Vancouver

Author

Blond, Martin Bæk ; Schnurr, Theresia Maria ; Rosenkilde, Mads ; Quist, Jonas Salling ; Gram, Anne Sofie ; Reichkendler, Michala Holm ; Auerbach, Pernille Landrock ; Nordby, Pernille ; Skovgaard, Lene Theil ; Ribel-Madsen, Rasmus ; Justesen, Johanne Marie ; Kilpeläinen, Tuomas Oskari ; Ploug, Thorkil ; Stallknecht, Bente Merete ; Hansen, Torben. / PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training. I: Physiological genomics. 2019 ; Bind 51, Nr. 6. s. 254-260.

Bibtex

@article{596ce64b4c004759b4481cad74121002,
title = "PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training",
abstract = "The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.",
author = "Blond, {Martin B{\ae}k} and Schnurr, {Theresia Maria} and Mads Rosenkilde and Quist, {Jonas Salling} and Gram, {Anne Sofie} and Reichkendler, {Michala Holm} and Auerbach, {Pernille Landrock} and Pernille Nordby and Skovgaard, {Lene Theil} and Rasmus Ribel-Madsen and Justesen, {Johanne Marie} and Kilpel{\"a}inen, {Tuomas Oskari} and Thorkil Ploug and Stallknecht, {Bente Merete} and Torben Hansen",
year = "2019",
month = jun,
day = "1",
doi = "10.1152/physiolgenomics.00101.2018",
language = "English",
volume = "51",
pages = "254--260",
journal = "Physiological Genomics",
issn = "1094-8341",
publisher = "American Physiological Society",
number = "6",

}

RIS

TY - JOUR

T1 - PPARG Pro12Ala Ala carriers exhibit greater improvements in peripheral insulin sensitivity in response to 12 weeks of aerobic exercise training

AU - Blond, Martin Bæk

AU - Schnurr, Theresia Maria

AU - Rosenkilde, Mads

AU - Quist, Jonas Salling

AU - Gram, Anne Sofie

AU - Reichkendler, Michala Holm

AU - Auerbach, Pernille Landrock

AU - Nordby, Pernille

AU - Skovgaard, Lene Theil

AU - Ribel-Madsen, Rasmus

AU - Justesen, Johanne Marie

AU - Kilpeläinen, Tuomas Oskari

AU - Ploug, Thorkil

AU - Stallknecht, Bente Merete

AU - Hansen, Torben

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.

AB - The Ala allele of PPARG Pro12Ala ( rs1801282 ) is associated with greater improvements to the glucose metabolism in exercise studies, but whether this extends to peripheral insulin sensitivity is unknown. Our objective was to investigate the effect of PPARG Pro12Ala on exercise-induced changes in peripheral insulin sensitivity. A total of 124 (91 Pro homozygotes and 33 Ala carriers) previously physically inactive healthy young men and women with overweight or class 1 obesity who completed a 12 wk aerobic exercise intervention were included in the analysis. All participants underwent a hyperinsulinemic euglycemic clamp before and after the 12 wk intervention. The prescribed exercise frequency was 5-7 days/wk, and the exercise energy expenditure was 2,100 4,200 kcal/wk for men and 1,600 kcal/wk for women. Insulin sensitivity improved significantly in both genotype groups. However, Ala carriers had a 1.13-fold (95% confidence interval 1.01; 1.26, P = 0.032) greater improvement in insulin sensitivity from baseline compared with Pro homozygotes. Our data support that PPARG Pro12Ala modifies the effect of aerobic exercise on peripheral insulin sensitivity.

U2 - 10.1152/physiolgenomics.00101.2018

DO - 10.1152/physiolgenomics.00101.2018

M3 - Journal article

C2 - 31074700

VL - 51

SP - 254

EP - 260

JO - Physiological Genomics

JF - Physiological Genomics

SN - 1094-8341

IS - 6

ER -

ID: 59319717