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Power estimations for non-primary outcomes in randomised clinical trials

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@article{6386ee8a39714030ae419225d9ee766b,
title = "Power estimations for non-primary outcomes in randomised clinical trials",
abstract = "OBJECTIVE AND METHODS: It is rare that trialists report power estimations of non-primary outcomes. In the present article, we will describe how to define a valid hierarchy of outcomes in a randomised clinical trial, to limit problems with Type I and Type II errors, using considerations on the clinical relevance of the outcomes and power estimations.CONCLUSION: Power estimations of non-primary outcomes may guide trialists in classifying non-primary outcomes as secondary or exploratory. The power estimations are simple and if they are used systematically, more appropriate outcome hierarchies can be defined, and trial results will become more interpretable.",
author = "Jakobsen, {Janus Christian} and Christian Ovesen and Per Winkel and J{\o}rgen Hilden and Christian Gluud and J{\o}rn Wetterslev",
note = "{\circledC} Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.",
year = "2019",
month = "6",
day = "6",
doi = "10.1136/bmjopen-2018-027092",
language = "English",
volume = "9",
pages = "e027092",
journal = "BMJ Paediatrics Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "6",

}

RIS

TY - JOUR

T1 - Power estimations for non-primary outcomes in randomised clinical trials

AU - Jakobsen, Janus Christian

AU - Ovesen, Christian

AU - Winkel, Per

AU - Hilden, Jørgen

AU - Gluud, Christian

AU - Wetterslev, Jørn

N1 - © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2019/6/6

Y1 - 2019/6/6

N2 - OBJECTIVE AND METHODS: It is rare that trialists report power estimations of non-primary outcomes. In the present article, we will describe how to define a valid hierarchy of outcomes in a randomised clinical trial, to limit problems with Type I and Type II errors, using considerations on the clinical relevance of the outcomes and power estimations.CONCLUSION: Power estimations of non-primary outcomes may guide trialists in classifying non-primary outcomes as secondary or exploratory. The power estimations are simple and if they are used systematically, more appropriate outcome hierarchies can be defined, and trial results will become more interpretable.

AB - OBJECTIVE AND METHODS: It is rare that trialists report power estimations of non-primary outcomes. In the present article, we will describe how to define a valid hierarchy of outcomes in a randomised clinical trial, to limit problems with Type I and Type II errors, using considerations on the clinical relevance of the outcomes and power estimations.CONCLUSION: Power estimations of non-primary outcomes may guide trialists in classifying non-primary outcomes as secondary or exploratory. The power estimations are simple and if they are used systematically, more appropriate outcome hierarchies can be defined, and trial results will become more interpretable.

U2 - 10.1136/bmjopen-2018-027092

DO - 10.1136/bmjopen-2018-027092

M3 - Journal article

VL - 9

SP - e027092

JO - BMJ Paediatrics Open

JF - BMJ Paediatrics Open

SN - 2044-6055

IS - 6

ER -

ID: 57347345