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Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Harvard

Rodríguez-Rodríguez, AE, Porrini, E, Hornum, M, Donate-Correa, J, Morales-Febles, R, Khemlani Ramchand, S, Molina Lima, MX & Torres, A 2021, 'Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update', Nephron, bind 145, nr. 4, s. 317-329. https://doi.org/10.1159/000514288

APA

Rodríguez-Rodríguez, A. E., Porrini, E., Hornum, M., Donate-Correa, J., Morales-Febles, R., Khemlani Ramchand, S., Molina Lima, M. X., & Torres, A. (2021). Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update. Nephron, 145(4), 317-329. https://doi.org/10.1159/000514288

CBE

Rodríguez-Rodríguez AE, Porrini E, Hornum M, Donate-Correa J, Morales-Febles R, Khemlani Ramchand S, Molina Lima MX, Torres A. 2021. Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update. Nephron. 145(4):317-329. https://doi.org/10.1159/000514288

MLA

Vancouver

Rodríguez-Rodríguez AE, Porrini E, Hornum M, Donate-Correa J, Morales-Febles R, Khemlani Ramchand S o.a. Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update. Nephron. 2021;145(4):317-329. https://doi.org/10.1159/000514288

Author

Rodríguez-Rodríguez, Ana Elena ; Porrini, Esteban ; Hornum, Mads ; Donate-Correa, Javier ; Morales-Febles, Raúl ; Khemlani Ramchand, Simran ; Molina Lima, María Xixiang ; Torres, Armando. / Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients : An Update. I: Nephron. 2021 ; Bind 145, Nr. 4. s. 317-329.

Bibtex

@article{50035baf60614f87a607f94dcb7334a6,
title = "Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update",
abstract = "Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20-30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.",
keywords = "Diabetes Mellitus/etiology, Humans, Insulin Resistance, Kidney Transplantation, Prediabetic State/etiology, Transplant Recipients",
author = "Rodr{\'i}guez-Rodr{\'i}guez, {Ana Elena} and Esteban Porrini and Mads Hornum and Javier Donate-Correa and Ra{\'u}l Morales-Febles and {Khemlani Ramchand}, Simran and {Molina Lima}, {Mar{\'i}a Xixiang} and Armando Torres",
note = "{\textcopyright} 2021 S. Karger AG, Basel.",
year = "2021",
doi = "10.1159/000514288",
language = "English",
volume = "145",
pages = "317--329",
journal = "Experimental Nephrology",
issn = "0028-2766",
publisher = "S./Karger AG",
number = "4",

}

RIS

TY - JOUR

T1 - Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients

T2 - An Update

AU - Rodríguez-Rodríguez, Ana Elena

AU - Porrini, Esteban

AU - Hornum, Mads

AU - Donate-Correa, Javier

AU - Morales-Febles, Raúl

AU - Khemlani Ramchand, Simran

AU - Molina Lima, María Xixiang

AU - Torres, Armando

N1 - © 2021 S. Karger AG, Basel.

PY - 2021

Y1 - 2021

N2 - Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20-30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.

AB - Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20-30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.

KW - Diabetes Mellitus/etiology

KW - Humans

KW - Insulin Resistance

KW - Kidney Transplantation

KW - Prediabetic State/etiology

KW - Transplant Recipients

UR - http://www.scopus.com/inward/record.url?scp=85105126325&partnerID=8YFLogxK

U2 - 10.1159/000514288

DO - 10.1159/000514288

M3 - Review

C2 - 33902027

VL - 145

SP - 317

EP - 329

JO - Experimental Nephrology

JF - Experimental Nephrology

SN - 0028-2766

IS - 4

ER -

ID: 70624346