@article{805481d599694368a78c0362c21a872c,
title = "Postprandial diabetic glucose tolerance is normalized by gastric bypass feeding as opposed to gastric feeding and is associated with exaggerated GLP-1 secretion: a case report",
abstract = "Objective: To examine after gastric bypass the effect of peroral vs. gastroduodenal feeding on glucose metabolism. Research Design and Methods: A type 2 diabetic patient was examined on two consecutive days 5 weeks after gastric bypass. A standard liquid meal was given, on the first day into the bypassed gastric remnant and on the second day perorally. Plasma glucose, insulin, C peptide, glucagon, incretin hormones, peptide YY and free fatty acids were measured. Results: Peroral feeding reduced 2-h-postprandial plasma glucose (7.8 vs. 11.1 mM) and incremental-area-under-the-glucose-curve (0.33 vs. 0.49 mMxmin) compared with gastroduodenal feeding . beta-cell function (iAUC(Cpeptide/Glu)) was more than 2-fold improved during peroral feeding and the GLP-1 response increased nearly 5-fold. Conclustions: Improvement in postprandial glucose metabolism after gastric bypass is an immediate and direct consequence of the gastrointestinal rearrangement, associated with exaggerated GLP-1 release and independent of changes in insulin sensitivity, weight-loss and caloric restriction.",
author = "Carsten Dirksen and Hansen, {Dorte L} and Sten Madsbad and Hvolris, {Lisbeth E} and Naver, {Lars S} and Holst, {Jens J} and Dorte Worm",
year = "2010",
doi = "10.2337/dc09-1374",
language = "English",
volume = "33",
pages = "375--7",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association",
number = "2",
}