Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Post-operative serious adverse events in a mixed surgical population - a retrospective register study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A marking of the cricothyroid membrane with extended neck returns to correct position after neck manipulation and repositioning

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association between transfusion of blood products and acute kidney injury following cardiac surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Preoperative high-dose Steroids in Total Knee and Hip Arthroplasty - Protocols for three randomized controlled trials

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. The Agents Intervening against Delirium in the Intensive Care Unit-Trial (AID-ICU trial):- a detailed statistical analysis plan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The PANSAID Randomized Clinical Trial: A pre-planned 1-year follow-up regarding harm

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Response

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The handling oxygenation targets in the intensive care unit (HOT-ICU) trial: Detailed statistical analysis plan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The number of surgical procedures is increasing, and knowledge of surgical risk factors, post-operative mortality and serious adverse events (SAE) is essential. The aim with our study was to determine the risk of a composite outcome of post-operative: death; myocardial infarction; pulmonary embolism; stroke; gastrointestinal bleeding; dialysis or reoperation.

METHODS: Data of surgical procedures in the period from January 1, 2012 to June 30, 2012 were retrieved from the Danish Anaesthesia Database (DAD). Follow-up of all patients undergoing hip or knee replacement, abdominal or gynaecological surgery was conducted retrieving data from The Danish Civil Registration System and the National Patient Register. Total observation time was from January 1, 2012 to June 6, 2013.

RESULTS: A total7449 adult patients were included in the final analysis. The risk of the composite outcome during a follow-up until 342 days after inclusion of the last patient was estimated to 8.3%, 95% Confidence Intervals (CI) (7.8-9.0), with a median observation time of 437 days (IQR 387-485, range 0-522). The risk of the composite outcome within 90- and 180-day follow-up of each patient was 4.8% (4.4-5.3) and 5.9% (5.4-6.5), respectively. Mortality within longest follow-up as well as 90 and 180 days post-operatively was 3.6% (3.1-4.0), 1.7% (1.4-2.0), and 2.2% (1.9-2.6), respectively.

CONCLUSION: We found a risk of one or more events in the composite outcome within 342 days after inclusion of the last patients of 8.3% (7.8-9.0). The results are applicable in estimations of adequate sample sizes in future clinical trials investigating effects of interventions on SAEs.

OriginalsprogEngelsk
TidsskriftActa Anaesthesiologica Scandinavica
Vol/bind60
Udgave nummer9
Sider (fra-til)1209-21
ISSN0001-5172
DOI
StatusUdgivet - 14 jul. 2016

ID: 48241050