Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Postoperative complications and waiting time for surgical intervention after radiologically guided drainage of intra-abdominal abscess in patients with Crohn's disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Preoperative high-dose glucocorticoids for early recovery after liver resection: randomized double-blinded trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Alterations in blood microbiota after colonic cancer surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Variation in training requirements within general surgery: comparison of 23 countries

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Mesh versus suture in elective repair of umbilical hernia: systematic review and meta-analysis

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  1. Reply

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  2. Severe ulcerative oesophagitis caused by primary Epstein-Barr virus infection in an immunocompetent individual

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Therapeutic thresholds and mechanisms for primary non-response to infliximab in inflammatory bowel disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • A El-Hussuna
  • M L M Karer
  • N N Uldall Nielsen
  • A Mujukian
  • P R Fleshner
  • I Iesalnieks
  • N Horesh
  • U Kopylov
  • H Jacoby
  • H M Al-Qaisi
  • F Colombo
  • G M Sampietro
  • M V Marino
  • M Ellebæk
  • C Steenholdt
  • N Sørensen
  • V Celentano
  • N Ladwa
  • J Warusavitarne
  • G Pellino
  • A Zeb
  • F Di Candido
  • L Hurtado-Pardo
  • M Frasson
  • L Kunovsky
  • A Yalcinkaya
  • O C Tatar
  • S Alonso
  • M Pera
  • A G Granero
  • C A Rodríguez
  • A Minaya
  • A Spinelli
  • N Qvist
Vis graf over relationer

BACKGROUND: In patients with active Crohn's disease (CD), treatment of intra-abdominal abscess usually comprises antibiotics and radiologically guided percutaneous drainage (PD) preceding surgery. The aim of this study was to investigate the risk of postoperative complications and identify the optimal time interval for surgical intervention after PD.

METHODS: A multicentre, international, retrospective cohort study was carried out. Details of patients with diagnosis of CD who underwent ultrasonography- or CT-guided PD were retrieved from hospital records using international classification of disease (ICD-10) diagnosis code for CD combined with procedure code for PD. Clinical variables were retrieved and the following outcomes were measured: 30-day postoperative overall complications, intra-abdominal septic complications, unplanned intraoperative adverse events, surgical-site infections, sepsis and pathological postoperative ileus, in addition to abscess recurrence. Patients were categorized into three groups according to the length of the interval from PD to surgery (1-14 days, 15-30 days and more than 30 days) for comparison of outcomes.

RESULTS: The cohort comprised 335 CD patients with PD followed by surgery. Median age was 33 (i.q.r. 24-44) years, 152 (45.4 per cent) were females, and median disease duration was 9 (i.q.r. 3.6-15) years. Overall, the 30-day postoperative complications rate was 32.2 per cent and the mortality rate was 1.5 per cent. After adjustment for co-variables, older age (odds ratio 1.03 (95 per cent c.i. 1.01 to 1.06), P < 0.012), residual abscess after PD (odds ratio 0.374 (95 per cent c.i. 0.19 to 0.74), P < 0.014), smoking (odds ratio 1.89 (95 per cent c.i. 1.01 to 3.53), P = 0.049) and low serum albumin concentration (odds ratio 0.921 (95 per cent c.i. 0.89 to 0.96), P < 0.001) were associated with higher rates of postoperative complications. A short waiting interval, less than 2 weeks after PD, was associated with a high incidence of abscess recurrence (odds ratio 0.59 (95 per cent c.i. 0.36 to 0.96), P = 0.042).

CONCLUSION: Smoking, low serum albumin concentration and older age were significantly associated with postoperative complications. An interval of at least 2 weeks after successful PD correlated with reduced risk of abscess recurrence.

TidsskriftBJS open
Udgave nummer5
Sider (fra-til)1-9
Antal sider9
StatusUdgivet - 6 sep. 2021

ID: 67612382