Postexercise nutrient intake enhances leg protein balance in early postmenopausal women

Lars Holm, Birgitte Esmarck, Charlotte Suetta, Keitaro Matsumoto, Tatsuya Doi, Masao Mizuno, Benjamin F Miller, Michael Kjaer

18 Citationer (Scopus)

Abstract

BACKGROUND: We investigated the effect of nutrient administration after a session of resistance exercise on muscle protein kinetics in six healthy, early postmenopausal women, in a crossover design of random and double-blinded administration of protein and carbohydrate (PC) or placebo (NON).

METHODS: Fasted participants received a primed-constant infusion of L-[ring-2H5]-phenylalanine. After 90 minutes of rest, the participants performed leg-resistance exercises followed by the oral supplementation. During the following 4 hours, net protein balance (NB) and rate of disappearance and appearance of phenylalanine were calculated from arterial-venous blood samples and blood flow measurements.

RESULTS: NB was elevated (p <.001) in the PC group compared to the NON group, and NB was not different from zero in the PC group, whereas it was negative in the NON group. Net balance results were supported by kinetic data from a reduced number of participants, showing that rate of disappearance was responsible for the initial (<1 hour) effect of PC, whereas a reduced rate of appearance enhanced the NB from 1.5 to 3 hours after training in the PC group.

CONCLUSION: In early postmenopausal women, nutrient ingestion following resistance exercise improved anabolism by enhancing NB in skeletal muscle.

OriginalsprogEngelsk
TidsskriftThe journals of gerontology. Series A, Biological sciences and medical sciences
Vol/bind60
Udgave nummer9
Sider (fra-til)1212-8
Antal sider7
ISSN1079-5006
StatusUdgivet - sep. 2005

Fingeraftryk

Dyk ned i forskningsemnerne om 'Postexercise nutrient intake enhances leg protein balance in early postmenopausal women'. Sammen danner de et unikt fingeraftryk.

Citationsformater