Possible risk factors and precipitants for migraine with aura in discordant twin-pairs: a population-based study

V Ulrich, J Olesen, M Gervil, M B Russell

57 Citationer (Scopus)

Abstract

The aim of the present study was to detect possible risk factors in migraine with aura (MA) by analysis of discordant twin-pairs. In a recent population-based twin study we established that environmental factors account for approximately 50% of the variation in liability to MA. A cohort of 5,360 same-gender twin-pairs from the general population was screened for migraine. All twin-pairs with possible migraine were interviewed by a physician. A questionnaire provided information about living conditions and lifestyle. Of the 169 discordant twin-pairs 51 were monozygotic and 118 were dizygotic twin-pairs. Several putative risk factors-schooling, education, marital status, smoking status and alcohol consumption-showed no association with MA. The presence of migraine without aura or tension-type headache did not increase the risk of MA. Stress and mental tension, and bright light precipitated attacks of MA in, respectively, 44% and 28% of the twins.

OriginalsprogEngelsk
TidsskriftCephalalgia : an international journal of headache
Vol/bind20
Udgave nummer9
Sider (fra-til)821-5
Antal sider5
ISSN0333-1024
DOI
StatusUdgivet - nov. 2000
Udgivet eksterntJa

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