Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis

Ditte Marie Kirkegaard-Klitbo; Flemming Bendtsen; Jens Lundgren; Susanne Dam Nielsen; Thomas Benfield; COCOMO study group

doi:10.1016/j.cgh.2019.10.024

Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis

Ditte Marie Kirkegaard-Klitbo, Flemming Bendtsen, Jens Lundgren, Susanne Dam Nielsen, Thomas Benfield, COCOMO study group

2 Citationer (Scopus)

Abstract

People living with human immunodeficiency virus (PLWH) are at higher risk of liver fibrosis compared with the general population. As liver fibrosis is independently associated with poor long-term liver related outcomes and mortality,1 early detection is extremely important. Liver biopsy is considered gold standard for the diagnosis of liver fibrosis. However, this invasive procedure is only suitable for a selected group of patients because of the risk of serious complications. We aimed to estimate the concordance between vibration-controlled transient elastography (VCTE) and simple noninvasive liver fibrosis scores-Fibrosis-4 index (FIB4), aspartate aminotransferase-to-platelet ratio index (APRI), and nonalcoholic fatty liver disease fibrosis score (NFS)-in PLWH without viral hepatitis.

Originalsprog	Engelsk
Tidsskrift	Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Vol/bind	18
Udgave nummer	13
Sider (fra-til)	3049-3050
Antal sider	2
ISSN	1542-3565
DOI	https://doi.org/10.1016/j.cgh.2019.10.024
Status	Udgivet - dec. 2020

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Kirkegaard-Klitbo, D. M., Bendtsen, F., Lundgren, J., Nielsen, S. D., Benfield, T., & COCOMO study group (2020). Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 18(13), 3049-3050. https://doi.org/10.1016/j.cgh.2019.10.024

Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis. / Kirkegaard-Klitbo, Ditte Marie ; Bendtsen, Flemming ; Lundgren, Jens et al.
I: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, Bind 18, Nr. 13, 12.2020, s. 3049-3050.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Kirkegaard-Klitbo, DM , Bendtsen, F , Lundgren, J , Nielsen, SD , Benfield, T & COCOMO study group 2020, 'Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis', Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, bind 18, nr. 13, s. 3049-3050. https://doi.org/10.1016/j.cgh.2019.10.024

Kirkegaard-Klitbo DM , Bendtsen F , Lundgren J , Nielsen SD , Benfield T, COCOMO study group. Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2020 dec.;18(13):3049-3050. doi: 10.1016/j.cgh.2019.10.024

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abstract = "People living with human immunodeficiency virus (PLWH) are at higher risk of liver fibrosis compared with the general population. As liver fibrosis is independently associated with poor long-term liver related outcomes and mortality,1 early detection is extremely important. Liver biopsy is considered gold standard for the diagnosis of liver fibrosis. However, this invasive procedure is only suitable for a selected group of patients because of the risk of serious complications. We aimed to estimate the concordance between vibration-controlled transient elastography (VCTE) and simple noninvasive liver fibrosis scores-Fibrosis-4 index (FIB4), aspartate aminotransferase-to-platelet ratio index (APRI), and nonalcoholic fatty liver disease fibrosis score (NFS)-in PLWH without viral hepatitis.",

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AU - Nielsen, Susanne Dam

AU - Benfield, Thomas

AU - COCOMO study group

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AB - People living with human immunodeficiency virus (PLWH) are at higher risk of liver fibrosis compared with the general population. As liver fibrosis is independently associated with poor long-term liver related outcomes and mortality,1 early detection is extremely important. Liver biopsy is considered gold standard for the diagnosis of liver fibrosis. However, this invasive procedure is only suitable for a selected group of patients because of the risk of serious complications. We aimed to estimate the concordance between vibration-controlled transient elastography (VCTE) and simple noninvasive liver fibrosis scores-Fibrosis-4 index (FIB4), aspartate aminotransferase-to-platelet ratio index (APRI), and nonalcoholic fatty liver disease fibrosis score (NFS)-in PLWH without viral hepatitis.

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Poor Concordance Between Liver Stiffness and Noninvasive Fibrosis Scores in HIV Infection Without Viral Hepatitis

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