TY - JOUR
T1 - Polymorphic variation in the androgen receptor gene: association with risk of testicular germ cell cancer and metastatic disease
AU - Västermark, Åke
AU - Giwercman, Yvonne Lundberg
AU - Hagströmer, Oskar
AU - Rajpert-De Meyts, Ewa
AU - Eberhard, Jakob
AU - Ståhl, Olof
AU - Cedermark, Gabriella Cohn
AU - Rastkhani, Hamideh
AU - Daugaard, Gedske
AU - Arver, Stefan
AU - Giwercman, Aleksander
N1 - Copyright © 2010 Elsevier Ltd. All rights reserved.
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Increasing incidence of testicular germ cell cancer (TGCC) is most probably related to environment and lifestyle. However, an underlying genetic predisposition may play a role and since sex steroids are assumed to be important for the rise and progression of TGCC, a study of androgen receptor (AR) gene polymorphisms in relation to the risk, histological type and progression of TGCC was undertaken. In 367 TGCC cases and 214 controls, AR CAG and GGN repeat lengths were determined and 11 haplotype-tagging single nucleotide polymorphisms (SNPs) were genotyped. By binary logistic regression, odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the risk of TGCC, non-seminoma versus seminoma and metastatic versus localised (stage I) disease. For the non-coding SNP, rs12014709, the minor genotype (G) was found in 10% of the cases and in 5.1% of the controls, conferring an OR of 2.07 (95% CI: 1.03-4.15) for having TGCC. Furthermore, short GGN (
AB - Increasing incidence of testicular germ cell cancer (TGCC) is most probably related to environment and lifestyle. However, an underlying genetic predisposition may play a role and since sex steroids are assumed to be important for the rise and progression of TGCC, a study of androgen receptor (AR) gene polymorphisms in relation to the risk, histological type and progression of TGCC was undertaken. In 367 TGCC cases and 214 controls, AR CAG and GGN repeat lengths were determined and 11 haplotype-tagging single nucleotide polymorphisms (SNPs) were genotyped. By binary logistic regression, odds ratios (ORs) and 95% confidence intervals (95% CI) were calculated for the risk of TGCC, non-seminoma versus seminoma and metastatic versus localised (stage I) disease. For the non-coding SNP, rs12014709, the minor genotype (G) was found in 10% of the cases and in 5.1% of the controls, conferring an OR of 2.07 (95% CI: 1.03-4.15) for having TGCC. Furthermore, short GGN (
U2 - 10.1016/j.ejca.2010.08.017
DO - 10.1016/j.ejca.2010.08.017
M3 - Journal article
C2 - 20880698
SN - 1879-0852
VL - 47
SP - 413
EP - 419
JO - European journal of cancer (Oxford, England : 1990)
JF - European journal of cancer (Oxford, England : 1990)
IS - 3
ER -