Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Point of no return for improvement of cartilage quality indicated by dGEMRIC before and after weight loss in patients with knee osteoarthritis: a cohort study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. The effects of rotation on radiological parameters in the spine

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The efficacy of using computer-aided detection (CAD) for detection of breast cancer in mammography screening: a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. New section editor: Cardiac Imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelFormidling

  4. Arterial spin labeling: a technical overview

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

Vis graf over relationer

Background It has been demonstrated that weight loss improves symptoms in obese subjects with knee osteoarthritis (KOA). A parallel change in cartilage morphology remains to be demonstrated. Purpose To demonstrate a parallel change in cartilage morphology. Material and Methods Obese patients with KOA were examined before and after weight loss over 16 weeks. Target knee joints were radiographically assessed by the Kellgren/Lawrence grading (KLG) system. Patients with KLG-1 and 2 changes in the lateral compartment were included. Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) was performed using intra-articular contrast. Results Nine patients with lateral KLG-1 and ten patients with lateral KLG-2 were studied. There were no group differences regarding the lateral compartment baseline dGEMRIC T1 values: median = 497 ms (KLG-1) and 533 ms (KLG-2) ( P = 0.12), or regarding reduction in body mass index (BMI) after 16 weeks: 12.8% versus 11.4% ( P = 0.74). In the KLG-1 group, several cases of increased dGEMRIC T1 values were seen and median value decreased significantly less than in KLG-2 group (15 ms versus 41 ms, P = 0.03) after weight loss. Conclusion Improvement of cartilage quality, assessed with dGEMRIC, after weight loss might be possible in early stage KOA (KLG-1), but not in later stage KOA (KLG-2). The results may suggest a point of no return for improvement of cartilage quality that should be tested in larger trials.

OriginalsprogEngelsk
TidsskriftActa Radiologica
Vol/bind59
Udgave nummer3
Sider (fra-til)336-340
Antal sider5
ISSN0284-1851
DOI
StatusUdgivet - mar. 2018

ID: 53652888