Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals

Kristine H Allin; Børge G Nordestgaard

doi:10.1007/s00125-013-3156-x

Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals

8 Citationer (Scopus)

Abstract

According to genome-wide association studies (GWAS) a locus in the HNF1A gene has pleiotropic effects on several metabolic traits. In a large single-centre study we used the intronic variant rs1183910 located in a region with no or low recombination rate as an instrument for the HNF1A locus to evaluate pleiotropic effects of this locus on the risk of developing type 2 diabetes, as well as on body composition and levels of non-fasting glucose, lipids, acute-phase reactants, and biomarkers of liver and pancreas function.

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	57
Udgave nummer	4
Sider (fra-til)	729-737
Antal sider	9
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-013-3156-x
Status	Udgivet - 19 jan. 2014

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10.1007/s00125-013-3156-x

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AU - Nordestgaard, Børge G

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AB - According to genome-wide association studies (GWAS) a locus in the HNF1A gene has pleiotropic effects on several metabolic traits. In a large single-centre study we used the intronic variant rs1183910 located in a region with no or low recombination rate as an instrument for the HNF1A locus to evaluate pleiotropic effects of this locus on the risk of developing type 2 diabetes, as well as on body composition and levels of non-fasting glucose, lipids, acute-phase reactants, and biomarkers of liver and pancreas function.

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DO - 10.1007/s00125-013-3156-x

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JO - Diabetologia

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ER -

Pleiotropic effects of HNF1A rs1183910 in a population-based study of 60,283 individuals

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