Abstract
The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic β-cell function by potentiating insulin secretion and β-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR) locus. Here we explored mechanisms that could explain the protective effects of GIP on islet function.
Originalsprog | Engelsk |
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Tidsskrift | Diabetes |
Vol/bind | 60 |
Udgave nummer | 9 |
Sider (fra-til) | 2424-33 |
Antal sider | 10 |
ISSN | 0012-1797 |
DOI | |
Status | Udgivet - sep. 2011 |