Pleiotropic effects of GIP on islet function involve osteopontin

Valeriya Lyssenko, Lena Eliasson, Olga Kotova, Kasper Pilgaard, Nils Wierup, Albert Salehi, Anna Wendt, Anna Jonsson, Yang Z De Marinis, Lisa M Berglund, Jalal Taneera, Alexander Balhuizen, Ola Hansson, Peter Osmark, Pontus Dunér, Charlotte Brøns, Alena Stancáková, Johanna Kuusisto, Marco Bugliani, Richa SaxenaEmma Ahlqvist, Timothy J Kieffer, Tiinamaija Tuomi, Bo Isomaa, Olle Melander, Emily Sonestedt, Marju Orho-Melander, Carl Martin Peter Nilsson, Sara Bonetti, Riccardo Bonadonna, Roberto Miccoli, Stefano Delprato, Piero Marchetti, Sten Madsbad, Pernille Hasse Busk Poulsen, Allan Vaag, Markku Laakso, Maria F Gomez, Leif Groop

74 Citationer (Scopus)

Abstract

The incretin hormone GIP (glucose-dependent insulinotropic polypeptide) promotes pancreatic β-cell function by potentiating insulin secretion and β-cell proliferation. Recently, a combined analysis of several genome-wide association studies (Meta-analysis of Glucose and Insulin-Related Traits Consortium [MAGIC]) showed association to postprandial insulin at the GIP receptor (GIPR) locus. Here we explored mechanisms that could explain the protective effects of GIP on islet function.
OriginalsprogEngelsk
TidsskriftDiabetes
Vol/bind60
Udgave nummer9
Sider (fra-til)2424-33
Antal sider10
ISSN0012-1797
DOI
StatusUdgivet - sep. 2011

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