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Region Hovedstaden - en del af Københavns Universitetshospital
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Platform for systems medicine research and diagnostic applications in psychotic disorders-The METSY project

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  1. Association between prior somatic disease and 5-year relapse risk among 11,856 incident patients with schizophrenia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The preferences of potential stakeholders in psychiatric genomic research regarding consent procedures and information delivery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Healthy minds 0-100 years: Optimising the use of European brain imaging cohorts ("Lifebrain")

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Diagnostic conversion to bipolar disorder in unipolar depressed patients participating in trials on antidepressants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Polyols and Branched Chained Amino Acids Are Associated with Present and Future Renal Impairment in Type 1 Diabetes

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  2. Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cell populations and molecular biomarkers in blood and urine characterise nephropathy in type 1 diabetes

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  4. Circulating metabolites are associated with present and future renal impairment in type 1 Diabetes

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  5. Low carbohydrate diet elevates blood sphingomyelin in people with type 1 diabetes

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  • Elisabeth Frank
  • Dieter Maier
  • Juha Pajula
  • Tommi Suvitaival
  • Faith Borgan
  • Markus Butz-Ostendorf
  • Alexander Fischer
  • Jarmo Hietala
  • Oliver Howes
  • Tuulia Hyötyläinen
  • Joost Janssen
  • Heikki Laurikainen
  • Carmen Moreno
  • Jaana Suvisaari
  • Mark Van Gils
  • Matej Orešič
Vis graf over relationer

Psychotic disorders are associated with metabolic abnormalities including alterations in glucose and lipid metabolism. A major challenge in the treatment of psychosis is to identify patients with vulnerable metabolic profiles who may be at risk of developing cardiometabolic co-morbidities. It is established that both central and peripheral metabolic organs use lipids to control energy balance and regulate peripheral insulin sensitivity. The endocannabinoid system, implicated in the regulation of glucose and lipid metabolism, has been shown to be dysregulated in psychosis. It is currently unclear how these endocannabinoid abnormalities relate to metabolic changes in psychosis. Here we review recent research in the field of metabolic co-morbidities in psychotic disorders as well as the methods to study them and potential links to the endocannabinoid system. We also describe the bioinformatics platforms developed in the EU project METSY for the investigations of the biological etiology in patients at risk of psychosis and in first episode psychosis patients. The METSY project was established with the aim to identify and evaluate multi-modal peripheral and neuroimaging markers that may be able to predict the onset and prognosis of psychiatric and metabolic symptoms in patients at risk of developing psychosis and first episode psychosis patients. Given the intrinsic complexity and widespread role of lipid metabolism, a systems biology approach which combines molecular, structural and functional neuroimaging methods with detailed metabolic characterisation and multi-variate network analysis is essential in order to identify how lipid dysregulation may contribute to psychotic disorders. A decision support system, integrating clinical, neuropsychological and neuroimaging data, was also developed in order to aid clinical decision making in psychosis. Knowledge of common and specific mechanisms may aid the etiopathogenic understanding of psychotic and metabolic disorders, facilitate early disease detection, aid treatment selection and elucidate new targets for pharmacological treatments.

OriginalsprogEngelsk
TidsskriftEuropean psychiatry : the journal of the Association of European Psychiatrists
Vol/bind50
Sider (fra-til)40-46
Antal sider6
ISSN0924-9338
DOI
StatusUdgivet - apr. 2018

ID: 52643662