TY - JOUR
T1 - Platelet count kinetics following Interruption of antiretroviral treatment
T2 - Results from the SMART study
AU - Zetterberg, Eva
AU - Neuhaus, Jacqueline
AU - Baker, Jason V
AU - Somboonwit, Charurut
AU - Llibre, Josep M
AU - Palfreeman, Adrian
AU - Chini, Maria
AU - Lundgren, Jens D
AU - for the INSIGHT SMART Study Group
PY - 2013
Y1 - 2013
N2 - OBJECTIVES:: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. DESIGN:: SMART patients from sites that determined platelets routinely. METHODS:: Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. RESULTS:: Platelet levels decreased in the DC group following randomization, but remained stable in the VS group [median (IQR) decline from study entry to month 4: -24,000/μL(-54,000-4,000) vs. 3000 (-22,000-24,000), respectively, p
AB - OBJECTIVES:: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. DESIGN:: SMART patients from sites that determined platelets routinely. METHODS:: Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. RESULTS:: Platelet levels decreased in the DC group following randomization, but remained stable in the VS group [median (IQR) decline from study entry to month 4: -24,000/μL(-54,000-4,000) vs. 3000 (-22,000-24,000), respectively, p
U2 - 10.1097/QAD.0b013e32835a104d
DO - 10.1097/QAD.0b013e32835a104d
M3 - Journal article
C2 - 23018440
SN - 0269-9370
VL - 27
SP - 59
EP - 68
JO - AIDS
JF - AIDS
IS - 1
ER -