Platelet count kinetics following Interruption of antiretroviral treatment: Results from the SMART study

Eva Zetterberg, Jacqueline Neuhaus, Jason V Baker, Charurut Somboonwit, Josep M Llibre, Adrian Palfreeman, Maria Chini, Jens D Lundgren, for the INSIGHT SMART Study Group

    11 Citationer (Scopus)

    Abstract

    OBJECTIVES:: To investigate the mechanisms of platelet kinetics in the SMART study that demonstrated excess mortality with CD4 guided episodic antiretroviral therapy (ART) (drug conservation [DC]) compared to continuous treatment (viral suppression [VS]). Follow up analyses of stored plasma samples demonstrated increased activation of both inflammatory and coagulation pathways after stopping ART. DESIGN:: SMART patients from sites that determined platelets routinely. METHODS:: Platelet counts were retrospectively collected from 2206 patients from visits at study entry, and during follow-up. D-dimer levels were measured at study entry, month 1, and 2. RESULTS:: Platelet levels decreased in the DC group following randomization, but remained stable in the VS group [median (IQR) decline from study entry to month 4: -24,000/μL(-54,000-4,000) vs. 3000 (-22,000-24,000), respectively, p 
    OriginalsprogEngelsk
    TidsskriftAIDS
    Vol/bind27
    Udgave nummer1
    Sider (fra-til)59-68
    ISSN0269-9370
    DOI
    StatusUdgivet - 2013

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