Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

Martin Sillesen; Pär I Johansson; Lars S Rasmussen; Guang Jin; Cecilie H Jepsen; Ayehsa M Imam; John Hwabejire; Jennifer Lu; Michael Duggan; George Velmahos; Marc deMoya; Hasan B Alam

doi:10.1097/TA.0b013e31828c7a6b

Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

Martin Sillesen, Pär I Johansson, Lars S Rasmussen, Guang Jin, Cecilie H Jepsen, Ayehsa M Imam, John Hwabejire, Jennifer Lu, Michael Duggan, George Velmahos, Marc deMoya, Hasan B Alam

68 Citationer (Scopus)

Abstract

Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.

Originalsprog	Engelsk
Tidsskrift	The journal of trauma and acute care surgery
Vol/bind	74
Udgave nummer	5
Sider (fra-til)	1252-9
Antal sider	8
DOI	https://doi.org/10.1097/TA.0b013e31828c7a6b
Status	Udgivet - maj 2013

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10.1097/TA.0b013e31828c7a6b

Citationsformater

Sillesen, M., Johansson, P. I., Rasmussen, L. S., Jin, G., Jepsen, C. H., Imam, A. M., Hwabejire, J., Lu, J., Duggan, M., Velmahos, G., deMoya, M., & Alam, H. B. (2013). Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage. The journal of trauma and acute care surgery, 74(5), 1252-9. https://doi.org/10.1097/TA.0b013e31828c7a6b

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abstract = "Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.",

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AU - Sillesen, Martin

AU - Johansson, Pär I

AU - Rasmussen, Lars S

AU - Jin, Guang

AU - Jepsen, Cecilie H

AU - Imam, Ayehsa M

AU - Hwabejire, John

AU - Lu, Jennifer

AU - Duggan, Michael

AU - Velmahos, George

AU - deMoya, Marc

AU - Alam, Hasan B

PY - 2013/5

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N2 - Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.

AB - Traumatic brain injury (TBI) and hemorrhage are the leading causes of trauma-related mortality. Both TBI and hemorrhage are associated with coagulation disturbances, including platelet dysfunction. We hypothesized that platelet dysfunction could be detected early after injury, and that this dysfunction would be associated with early activation, as measured by circulating levels of platelet activation markers.

U2 - 10.1097/TA.0b013e31828c7a6b

DO - 10.1097/TA.0b013e31828c7a6b

M3 - Journal article

C2 - 23609275

SN - 2163-0763

VL - 74

SP - 1252

EP - 1259

JO - The journal of trauma and acute care surgery

JF - The journal of trauma and acute care surgery

IS - 5

ER -

Platelet activation and dysfunction in a large-animal model of traumatic brain injury and hemorrhage

Abstract

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