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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Plasticity of cerebrovascular smooth muscle cells after subarachnoid hemorrhage

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Elevated miR-9 in Cerebrospinal Fluid Is Associated with Poor Functional Outcome After Subarachnoid Hemorrhage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Infections Up to 76 Days After Stroke Increase Disability and Death

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  3. Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

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Vis graf over relationer

Subarachnoid hemorrhage (SAH) is most often followed by a delayed phase of cerebral ischemia which is associated with high morbidity and mortality rates. The causes underlying this delayed phase are still unsettled, but are believed to include cerebral vasospasm, cortical spreading depression, inflammatory reactions, and microthrombosis. Additionally, a large body of evidence indicates that vascular plasticity plays an important role in SAH pathophysiology, and this review aims to summarize our current knowledge on the phenotypic changes of vascular smooth muscle cells of the cerebral vasculature following SAH. In light of the emerging view that the whole cerebral vasculature and the cells of the brain parenchyma should be viewed as one integrated neurovascular network, phenotypical changes are discussed both for the cerebral arteries and the microvasculature. Furthermore, the intracellular signaling involved in the vascular plasticity is discussed with a focus on the Raf-MEK1/2-ERK1/2 pathway which seems to play a crucial role in SAH pathology.

OriginalsprogEngelsk
TidsskriftTranslational Stroke Research
Vol/bind5
Udgave nummer3
Sider (fra-til)365-76
Antal sider12
ISSN1868-4483
DOI
StatusUdgivet - jun. 2014

ID: 44846614