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Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort

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Harvard

Adamou, R, Dechavanne, C, Sadissou, I, d'Almeida, T, Bouraima, A, Sonon, P, Amoussa, R, Cottrell, G, Le Port, A, Theisen, M, Remarque, EJ, Longacre, S, Moutairou, K, Massougbodji, A, Luty, AJF, Nuel, G, Migot-Nabias, F, Sanni, A, Garcia, A, Milet, J & Courtin, D 2019, 'Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort', Malaria Journal, bind 18, nr. 1, s. 194. https://doi.org/10.1186/s12936-019-2831-x

APA

Adamou, R., Dechavanne, C., Sadissou, I., d'Almeida, T., Bouraima, A., Sonon, P., Amoussa, R., Cottrell, G., Le Port, A., Theisen, M., Remarque, E. J., Longacre, S., Moutairou, K., Massougbodji, A., Luty, A. J. F., Nuel, G., Migot-Nabias, F., Sanni, A., Garcia, A., ... Courtin, D. (2019). Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort. Malaria Journal, 18(1), 194. https://doi.org/10.1186/s12936-019-2831-x

CBE

Adamou R, Dechavanne C, Sadissou I, d'Almeida T, Bouraima A, Sonon P, Amoussa R, Cottrell G, Le Port A, Theisen M, Remarque EJ, Longacre S, Moutairou K, Massougbodji A, Luty AJF, Nuel G, Migot-Nabias F, Sanni A, Garcia A, Milet J, Courtin D. 2019. Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort. Malaria Journal. 18(1):194. https://doi.org/10.1186/s12936-019-2831-x

MLA

Vancouver

Author

Adamou, Rafiou ; Dechavanne, Célia ; Sadissou, Ibrahim ; d'Almeida, Tania ; Bouraima, Aziz ; Sonon, Paulin ; Amoussa, Roukiyath ; Cottrell, Gilles ; Le Port, Agnès ; Theisen, Michael ; Remarque, Edmond J ; Longacre, Shirley ; Moutairou, Kabirou ; Massougbodji, Achille ; Luty, Adrian J F ; Nuel, Gregory ; Migot-Nabias, Florence ; Sanni, Ambaliou ; Garcia, André ; Milet, Jacqueline ; Courtin, David. / Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort. I: Malaria Journal. 2019 ; Bind 18, Nr. 1. s. 194.

Bibtex

@article{b8b0acbefdb34296b6fbd8efe62beec8,
title = "Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort",
abstract = "BACKGROUND: Substantial evidence indicates that cytophilic IgG responses to Plasmodium falciparum merozoite antigens play a role in protection from malaria. The specific targets mediating immunity remain unclear. Evaluating antibody responses in infants naturally-exposed to malaria will allow to better understand the establishment of anti-malarial immunity and to contribute to a vaccine development by identifying the most appropriate merozoite candidate antigens.METHODS: The study was based on parasitological and clinical active follow-up of infants from birth to 18 months of age conducted in the Tori Bossito area of southern Benin. For 399 infants, plasma levels of cytophilic IgG antibodies with specificity for five asexual stage malaria vaccine candidate antigens were determined by ELISA in infants' peripheral blood at 6, 9, 12 and 15 months of age. Multivariate mixed logistic model was used to investigate the association between antibody levels and anti-malarial protection in the trimester following the IgG quantification. Moreover, the concentrations of merozoite antigen-specific IgG were compared between a group of infants apparently able to control asymptomatic malaria infection (CAIG) and a group of infants with no control of malaria infection (Control group (NCIG)). Protective effect of antibodies was also assessed after 15 months of malaria exposure with a Cox regression model adjusted on environmental risk.RESULTS: Cytophilic IgG responses to AMA1, MSP1, MSP2-3D7, MSP2-FC27, MSP3 and GLURP R2 were associated with increasing malarial infection risk in univariate analysis. The multivariate mixed model showed that IgG1 and IgG3 to AMA1 were associated with an increased risk of malarial infection. However infants from CAIG (n = 53) had significantly higher AMA1-, MSP2-FC27-, MSP3-specific IgG1 and AMA1-, MSP1-, MSP2-FC27-, MSP3 and GLURP-R2-specific IgG3 than those from NCIG (n = 183). The latter IgG responses were not associated with protection against clinical malaria in the whole cohort when protective effect is assessed after 15 months of malaria exposition.CONCLUSION: In this cohort, merozoite antigen-specific cytophilic IgG levels represent a marker of malaria exposure in infants from 6 to 18 months of age. However, infants with resolution of asymptomatic infection (CAIG) seem to have acquired naturally immunity against P. falciparum. This observation is encouraging in the context of the development of multitarget P. falciparum vaccines.",
keywords = "Antibodies, Protozoan/blood, Antigens, Protozoan/immunology, Benin, Enzyme-Linked Immunosorbent Assay, Female, Humans, Immunoglobulin G/blood, Infant, Infant, Newborn, Longitudinal Studies, Malaria, Falciparum/immunology, Male, Plasmodium falciparum/immunology, Pregnancy, Protozoan Proteins/immunology, Surveys and Questionnaires",
author = "Rafiou Adamou and C{\'e}lia Dechavanne and Ibrahim Sadissou and Tania d'Almeida and Aziz Bouraima and Paulin Sonon and Roukiyath Amoussa and Gilles Cottrell and {Le Port}, Agn{\`e}s and Michael Theisen and Remarque, {Edmond J} and Shirley Longacre and Kabirou Moutairou and Achille Massougbodji and Luty, {Adrian J F} and Gregory Nuel and Florence Migot-Nabias and Ambaliou Sanni and Andr{\'e} Garcia and Jacqueline Milet and David Courtin",
year = "2019",
month = jun,
day = "11",
doi = "10.1186/s12936-019-2831-x",
language = "English",
volume = "18",
pages = "194",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Plasmodium falciparum merozoite surface antigen-specific cytophilic IgG and control of malaria infection in a Beninese birth cohort

AU - Adamou, Rafiou

AU - Dechavanne, Célia

AU - Sadissou, Ibrahim

AU - d'Almeida, Tania

AU - Bouraima, Aziz

AU - Sonon, Paulin

AU - Amoussa, Roukiyath

AU - Cottrell, Gilles

AU - Le Port, Agnès

AU - Theisen, Michael

AU - Remarque, Edmond J

AU - Longacre, Shirley

AU - Moutairou, Kabirou

AU - Massougbodji, Achille

AU - Luty, Adrian J F

AU - Nuel, Gregory

AU - Migot-Nabias, Florence

AU - Sanni, Ambaliou

AU - Garcia, André

AU - Milet, Jacqueline

AU - Courtin, David

PY - 2019/6/11

Y1 - 2019/6/11

N2 - BACKGROUND: Substantial evidence indicates that cytophilic IgG responses to Plasmodium falciparum merozoite antigens play a role in protection from malaria. The specific targets mediating immunity remain unclear. Evaluating antibody responses in infants naturally-exposed to malaria will allow to better understand the establishment of anti-malarial immunity and to contribute to a vaccine development by identifying the most appropriate merozoite candidate antigens.METHODS: The study was based on parasitological and clinical active follow-up of infants from birth to 18 months of age conducted in the Tori Bossito area of southern Benin. For 399 infants, plasma levels of cytophilic IgG antibodies with specificity for five asexual stage malaria vaccine candidate antigens were determined by ELISA in infants' peripheral blood at 6, 9, 12 and 15 months of age. Multivariate mixed logistic model was used to investigate the association between antibody levels and anti-malarial protection in the trimester following the IgG quantification. Moreover, the concentrations of merozoite antigen-specific IgG were compared between a group of infants apparently able to control asymptomatic malaria infection (CAIG) and a group of infants with no control of malaria infection (Control group (NCIG)). Protective effect of antibodies was also assessed after 15 months of malaria exposure with a Cox regression model adjusted on environmental risk.RESULTS: Cytophilic IgG responses to AMA1, MSP1, MSP2-3D7, MSP2-FC27, MSP3 and GLURP R2 were associated with increasing malarial infection risk in univariate analysis. The multivariate mixed model showed that IgG1 and IgG3 to AMA1 were associated with an increased risk of malarial infection. However infants from CAIG (n = 53) had significantly higher AMA1-, MSP2-FC27-, MSP3-specific IgG1 and AMA1-, MSP1-, MSP2-FC27-, MSP3 and GLURP-R2-specific IgG3 than those from NCIG (n = 183). The latter IgG responses were not associated with protection against clinical malaria in the whole cohort when protective effect is assessed after 15 months of malaria exposition.CONCLUSION: In this cohort, merozoite antigen-specific cytophilic IgG levels represent a marker of malaria exposure in infants from 6 to 18 months of age. However, infants with resolution of asymptomatic infection (CAIG) seem to have acquired naturally immunity against P. falciparum. This observation is encouraging in the context of the development of multitarget P. falciparum vaccines.

AB - BACKGROUND: Substantial evidence indicates that cytophilic IgG responses to Plasmodium falciparum merozoite antigens play a role in protection from malaria. The specific targets mediating immunity remain unclear. Evaluating antibody responses in infants naturally-exposed to malaria will allow to better understand the establishment of anti-malarial immunity and to contribute to a vaccine development by identifying the most appropriate merozoite candidate antigens.METHODS: The study was based on parasitological and clinical active follow-up of infants from birth to 18 months of age conducted in the Tori Bossito area of southern Benin. For 399 infants, plasma levels of cytophilic IgG antibodies with specificity for five asexual stage malaria vaccine candidate antigens were determined by ELISA in infants' peripheral blood at 6, 9, 12 and 15 months of age. Multivariate mixed logistic model was used to investigate the association between antibody levels and anti-malarial protection in the trimester following the IgG quantification. Moreover, the concentrations of merozoite antigen-specific IgG were compared between a group of infants apparently able to control asymptomatic malaria infection (CAIG) and a group of infants with no control of malaria infection (Control group (NCIG)). Protective effect of antibodies was also assessed after 15 months of malaria exposure with a Cox regression model adjusted on environmental risk.RESULTS: Cytophilic IgG responses to AMA1, MSP1, MSP2-3D7, MSP2-FC27, MSP3 and GLURP R2 were associated with increasing malarial infection risk in univariate analysis. The multivariate mixed model showed that IgG1 and IgG3 to AMA1 were associated with an increased risk of malarial infection. However infants from CAIG (n = 53) had significantly higher AMA1-, MSP2-FC27-, MSP3-specific IgG1 and AMA1-, MSP1-, MSP2-FC27-, MSP3 and GLURP-R2-specific IgG3 than those from NCIG (n = 183). The latter IgG responses were not associated with protection against clinical malaria in the whole cohort when protective effect is assessed after 15 months of malaria exposition.CONCLUSION: In this cohort, merozoite antigen-specific cytophilic IgG levels represent a marker of malaria exposure in infants from 6 to 18 months of age. However, infants with resolution of asymptomatic infection (CAIG) seem to have acquired naturally immunity against P. falciparum. This observation is encouraging in the context of the development of multitarget P. falciparum vaccines.

KW - Antibodies, Protozoan/blood

KW - Antigens, Protozoan/immunology

KW - Benin

KW - Enzyme-Linked Immunosorbent Assay

KW - Female

KW - Humans

KW - Immunoglobulin G/blood

KW - Infant

KW - Infant, Newborn

KW - Longitudinal Studies

KW - Malaria, Falciparum/immunology

KW - Male

KW - Plasmodium falciparum/immunology

KW - Pregnancy

KW - Protozoan Proteins/immunology

KW - Surveys and Questionnaires

U2 - 10.1186/s12936-019-2831-x

DO - 10.1186/s12936-019-2831-x

M3 - Journal article

C2 - 31185998

VL - 18

SP - 194

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

IS - 1

ER -

ID: 59238836