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Plasmodium falciparum Infection Early in Pregnancy has Profound Consequences for Fetal Growth

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@article{62a8cc17da7a4661bf0fd6977b0e5c32,
title = "Plasmodium falciparum Infection Early in Pregnancy has Profound Consequences for Fetal Growth",
abstract = "Malaria during pregnancy constitutes a large health problem in areas of endemicity. The World Health Organization recommends that interventions are initiated at the first antenatal visit, and these improve pregnancy outcomes. This study evaluated fetal growth by ultrasonography and birth outcomes in women who were infected prior to the first antenatal visit (gestational age, <120 days) and not later in pregnancy. Compared with uninfected controls, women with early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of 212 and 253 days (difference between means, 107 g [95{\%} confidence interval {CI}, 26-188]; P = .0099) and a shorter pregnancy duration (difference between means, 6.6 days [95{\%} CI, 1.0-112.5]; P = .0087). The birth weight (difference between means, 221 g [95{\%} CI, 6-436]; P = .044) and the placental weight (difference between means, 84 g [95{\%} CI, 18-150]; P = .013) at term were also reduced. The study suggests that early exposure to P. falciparum, which is not targeted for prevention by current control strategies, has a profound impact on fetal growth, pregnancy duration, and placental weight at term.",
keywords = "Journal Article",
author = "Christentze Schmiegelow and Sungwa Matondo and Minja, {Daniel T R} and Mafalda Resende and Caroline Pehrson and Nielsen, {Birgitte Bruun} and Raimos Olomi and Nielsen, {Morten A} and Philippe Deloron and Ali Salanti and John Lusingu and Theander, {Thor G}",
note = "{\circledC} The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2017",
month = "12",
day = "19",
doi = "10.1093/infdis/jix530",
language = "English",
volume = "216",
pages = "1601--1610",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "University of Chicago Press",
number = "12",

}

RIS

TY - JOUR

T1 - Plasmodium falciparum Infection Early in Pregnancy has Profound Consequences for Fetal Growth

AU - Schmiegelow, Christentze

AU - Matondo, Sungwa

AU - Minja, Daniel T R

AU - Resende, Mafalda

AU - Pehrson, Caroline

AU - Nielsen, Birgitte Bruun

AU - Olomi, Raimos

AU - Nielsen, Morten A

AU - Deloron, Philippe

AU - Salanti, Ali

AU - Lusingu, John

AU - Theander, Thor G

N1 - © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2017/12/19

Y1 - 2017/12/19

N2 - Malaria during pregnancy constitutes a large health problem in areas of endemicity. The World Health Organization recommends that interventions are initiated at the first antenatal visit, and these improve pregnancy outcomes. This study evaluated fetal growth by ultrasonography and birth outcomes in women who were infected prior to the first antenatal visit (gestational age, <120 days) and not later in pregnancy. Compared with uninfected controls, women with early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of 212 and 253 days (difference between means, 107 g [95% confidence interval {CI}, 26-188]; P = .0099) and a shorter pregnancy duration (difference between means, 6.6 days [95% CI, 1.0-112.5]; P = .0087). The birth weight (difference between means, 221 g [95% CI, 6-436]; P = .044) and the placental weight (difference between means, 84 g [95% CI, 18-150]; P = .013) at term were also reduced. The study suggests that early exposure to P. falciparum, which is not targeted for prevention by current control strategies, has a profound impact on fetal growth, pregnancy duration, and placental weight at term.

AB - Malaria during pregnancy constitutes a large health problem in areas of endemicity. The World Health Organization recommends that interventions are initiated at the first antenatal visit, and these improve pregnancy outcomes. This study evaluated fetal growth by ultrasonography and birth outcomes in women who were infected prior to the first antenatal visit (gestational age, <120 days) and not later in pregnancy. Compared with uninfected controls, women with early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of 212 and 253 days (difference between means, 107 g [95% confidence interval {CI}, 26-188]; P = .0099) and a shorter pregnancy duration (difference between means, 6.6 days [95% CI, 1.0-112.5]; P = .0087). The birth weight (difference between means, 221 g [95% CI, 6-436]; P = .044) and the placental weight (difference between means, 84 g [95% CI, 18-150]; P = .013) at term were also reduced. The study suggests that early exposure to P. falciparum, which is not targeted for prevention by current control strategies, has a profound impact on fetal growth, pregnancy duration, and placental weight at term.

KW - Journal Article

U2 - 10.1093/infdis/jix530

DO - 10.1093/infdis/jix530

M3 - Journal article

VL - 216

SP - 1601

EP - 1610

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 12

ER -

ID: 52362837