TY - JOUR
T1 - Plasmid-borne AmpC beta-lactamases
AU - Walther-Rasmussen, Jan
AU - Høiby, Niels
PY - 2002/6
Y1 - 2002/6
N2 - Historically, it was thought that ampC genes encoding class C beta-lactamases were located solely on the chromosome but, within the last 12 years, an increasing number of ampC genes have been found on plasmids. These have mostly been acquired by ampC-deficient pathogenic bacteria, which consequently are supplied with new and additional resistance phenotypes. This review discusses the phylogenetic origin of the plasmid-encoded AmpC beta-lactamases, their occurrence, and mode of spread, as well as their hydrolytic properties.
AB - Historically, it was thought that ampC genes encoding class C beta-lactamases were located solely on the chromosome but, within the last 12 years, an increasing number of ampC genes have been found on plasmids. These have mostly been acquired by ampC-deficient pathogenic bacteria, which consequently are supplied with new and additional resistance phenotypes. This review discusses the phylogenetic origin of the plasmid-encoded AmpC beta-lactamases, their occurrence, and mode of spread, as well as their hydrolytic properties.
KW - Bacterial Proteins
KW - Gram-Negative Bacteria/enzymology
KW - Molecular Sequence Data
KW - Phylogeny
KW - Plasmids/genetics
KW - Structure-Activity Relationship
KW - beta-Lactam Resistance/genetics
KW - beta-Lactamases/genetics
U2 - 10.1139/w02-039
DO - 10.1139/w02-039
M3 - Review
C2 - 12166675
SN - 0008-4166
VL - 48
SP - 479
EP - 493
JO - Canadian journal of microbiology
JF - Canadian journal of microbiology
IS - 6
ER -