Plasma levels of mannose-binding lectin and future risk of venous thromboembolism

Robin A Liang, Ina I Høiland, Thor Ueland, Pål Aukrust, Omri Snir, Kristian Hindberg, Sigrid K Braekkan, Peter Garred, Tom E Mollnes, John-Bjarne Hansen

14 Citationer (Scopus)

Abstract

BACKGROUND: Animal and observational studies have suggested a pathophysiological role for complement in venous thromboembolism (VTE), but the initiating mechanisms are unknown. Mannose-binding lectin (MBL) bound to altered host cells leads to activation of the lectin complement pathway, and both high and low MBL levels have been implicated in the pathophysiology of cardiovascular disease.

OBJECTIVES: To investigate the association between plasma MBL levels and future risk of incident VTE.

METHODS: We conducted a nested case-control study in 417 VTE patients and 849 age-matched and sex-matched controls derived from the general population (Tromsø Study). Plasma MBL levels were measured using enzyme-linked immunosorbent assay. Logistic regression models were used to estimate odds ratio (OR) for VTE across quartiles of plasma MBL levels.

RESULTS: Subjects with plasma MBL levels in the lowest quartile (<435 ng/mL) had a reduced OR for overall VTE (OR 0.79, 95% confidence interval [CI]: 0.56-1.10) and for DVT (OR 0.70, 95% CI: 0.47-1.04) compared to those with MBL in the highest quartile (≥2423 ng/mL) after multivariable adjustments. For VTE, DVT, and pulmonary embolism (PE) the ORs decreased substantially with decreasing time between blood sampling and VTE event.

CONCLUSIONS: Our findings suggest that low plasma MBL levels are associated with reduced risk of VTE, and DVT in particular.

OriginalsprogEngelsk
TidsskriftJournal of thrombosis and haemostasis : JTH
Vol/bind17
Udgave nummer10
Sider (fra-til)1661-1669
Antal sider9
ISSN1538-7933
DOI
StatusUdgivet - okt. 2019

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