Plasma growth differentiation factor-15 independently predicts all-cause and cardiovascular mortality as well as deterioration of kidney function in type 1 diabetic patients with nephropathy

Maria Stenkil Lajer, Anders Jorsal, Lise Tarnow, Hans-Henrik Parving, Peter Rossing

    105 Citationer (Scopus)

    Abstract

    Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression is induced in the heart in response to ischemia and in atherosclerotic plaques. The aim of this study was to investigate GDF-15 levels in relation to all-cause mortality, cardiovascular mortality and morbidity, decline in glomerular filtration rate (GFR), and progression toward end-stage renal disease (ESRD).
    OriginalsprogEngelsk
    TidsskriftDiabetes Care
    Vol/bind33
    Udgave nummer7
    Sider (fra-til)1567-72
    Antal sider6
    ISSN0149-5992
    DOI
    StatusUdgivet - 1 jul. 2010

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