Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake

Jakob Ryskjaer; Carolyn F. Deacon; Richard D Carr; Thure Krarup; Sten Madsbad; Jens Juul Holst; Tina Vilsbøll

doi:10.1530/eje.1.02221

Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake

Jakob Ryskjaer, Carolyn F. Deacon, Richard D Carr, Thure Krarup, Sten Madsbad, Jens Juul Holst, Tina Vilsbøll

167 Citationer (Scopus)

Abstract

Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide are incretin hormones, secreted in response to meal ingestion. The incretin hormones stimulate insulin secretion and are essential for the maintenance of normal plasma glucose concentrations. Both incretin hormones are metabolized quickly by the enzyme dipeptidyl peptidase-IV (DPP-IV). It is well known that type-2 diabetic patients have an impaired incretin effect. Therefore, the aim of the present study was to investigate plasma DPP-IV activity in the fasting and the postprandial state in type-2 diabetic patients and control subjects.

Originalsprog	Engelsk
Tidsskrift	European Journal of Endocrinology
Vol/bind	155
Udgave nummer	3
Sider (fra-til)	485-93
Antal sider	9
ISSN	0804-4643
DOI	https://doi.org/10.1530/eje.1.02221
Status	Udgivet - 1 sep. 2006

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10.1530/eje.1.02221

Citationsformater

Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake. / Ryskjaer, Jakob; Deacon, Carolyn F.; Carr, Richard D et al.
I: European Journal of Endocrinology, Bind 155, Nr. 3, 01.09.2006, s. 485-93.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide are incretin hormones, secreted in response to meal ingestion. The incretin hormones stimulate insulin secretion and are essential for the maintenance of normal plasma glucose concentrations. Both incretin hormones are metabolized quickly by the enzyme dipeptidyl peptidase-IV (DPP-IV). It is well known that type-2 diabetic patients have an impaired incretin effect. Therefore, the aim of the present study was to investigate plasma DPP-IV activity in the fasting and the postprandial state in type-2 diabetic patients and control subjects.",

author = "Jakob Ryskjaer and Deacon, {Carolyn F.} and Carr, {Richard D} and Thure Krarup and Sten Madsbad and Holst, {Jens Juul} and Tina Vilsb{\o}ll",

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AU - Ryskjaer, Jakob

AU - Deacon, Carolyn F.

AU - Carr, Richard D

AU - Krarup, Thure

AU - Madsbad, Sten

AU - Holst, Jens Juul

AU - Vilsbøll, Tina

PY - 2006/9/1

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N2 - Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide are incretin hormones, secreted in response to meal ingestion. The incretin hormones stimulate insulin secretion and are essential for the maintenance of normal plasma glucose concentrations. Both incretin hormones are metabolized quickly by the enzyme dipeptidyl peptidase-IV (DPP-IV). It is well known that type-2 diabetic patients have an impaired incretin effect. Therefore, the aim of the present study was to investigate plasma DPP-IV activity in the fasting and the postprandial state in type-2 diabetic patients and control subjects.

AB - Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide are incretin hormones, secreted in response to meal ingestion. The incretin hormones stimulate insulin secretion and are essential for the maintenance of normal plasma glucose concentrations. Both incretin hormones are metabolized quickly by the enzyme dipeptidyl peptidase-IV (DPP-IV). It is well known that type-2 diabetic patients have an impaired incretin effect. Therefore, the aim of the present study was to investigate plasma DPP-IV activity in the fasting and the postprandial state in type-2 diabetic patients and control subjects.

U2 - 10.1530/eje.1.02221

DO - 10.1530/eje.1.02221

M3 - Journal article

C2 - 16914604

SN - 0804-4643

VL - 155

SP - 485

EP - 493

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

IS - 3

ER -

Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake

Abstract

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