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Plasma dihydroxyphenylglycol (DHPG) as an index of diabetic autonomic neuropathy

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  1. Gastrointestinal mean transit times in young and middle-aged healthy subjects.

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  2. Forearm metabolism during infusion of adrenaline: comparison of the dominant and non-dominant arm

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  3. Simplified scintigraphic methods for measuring gastrointestinal transit times.

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  4. Transperitoneal transport in diabetic and non-diabetic patients on peritoneal dialysis

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Forearm venous plasma noradrenalin and dihydroxyphenylglycol (DHPG) concentrations were measured in eight diabetic patients with and eight diabetic patients without neuropathy. Plasma noradrenalin was on average the same in patients with and without neuropathy and correlated to serum creatinine. Plasma DHPG concentrations were significantly reduced in patients with autonomic neuropathy as compared to patients without neuropathy (P less than 0.05). A low plasma DHPG/noradrenalin ratio in forearm venous blood identified all patients with autonomic neuropathy except one (P less than 0.02). Measuring the plasma DHPG/noradrenalin ratio may circumvent the problem of unrepresentative noradrenalin release from the forearm.
OriginalsprogEngelsk
TidsskriftClinical physiology (Oxford, England)
Vol/bind8
Udgave nummer6
Sider (fra-til)577-80
Antal sider4
ISSN0144-5979
StatusUdgivet - dec. 1988

ID: 40238624