Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pivotal Role of Preexisting Pathogen-Specific Antibodies in the Development of Necrotizing Soft-Tissue Infections

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. High-Throughput Sequencing-Based Investigation of Viruses in Human Cancers by Multienrichment Approach

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. The effect of interrupted/deferred antiretroviral therapy on disease risk: A SMART and START Combined Analysis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Only minor stem cell mobilization in head and neck irradiated patients treated with hyperbaric oxygen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Molecular profiling of tissue biopsies reveals unique signatures associated with streptococcal necrotizing soft tissue infections

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Eubs president's message

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

  • INFECT study group
  • Anshu Babbar
  • Trond Bruun
  • Ole Hyldegaard
  • Michael Nekludov
  • Per Arnell
  • Dietmar H Pieper
  • Andreas Itzek
Vis graf over relationer

Background: Necrotizing soft-tissue infections (NSTI) are the most severe form of bacterial-induced tissue pathology. Their unpredictable onset and rapid development into life-threatening conditions considerably complicate patient treatment. Understanding the risk factors for NSTI in individual patients is necessary for selecting the appropriate therapeutic option.

Methods: We investigated the role of pathogen-specific antibodies in the manifestation of NSTI by performing a comparative serologic approach, using plasma samples and bacterial isolates from patients with clinical NSTIs or nonnecrotizing STIs caused by Streptococcus pyogenes. We also evaluated the potential beneficial effect of intravenous immunoglobulin (IVIG) treatment.

Results: We identified a hitherto overlooked state of serologic susceptibility in patients with NSTIs during the earliest stages of the infection that is potentially linked to disease progression. Thus, all patients with NSTIs included in this study exhibited a deficiency in specific antibodies directed against the causative S. pyogenes strains and the majority of their exotoxins during the initial stage of the infection. We also showed that the clinical use of IVIG during the course of infection compensates the observed antibody deficiency but is unable to halt the disease progression, once tissue necrosis has developed.

Conclusion: These observations emphasize the requirement of preexisting pathogen-specific antibodies to prevent the irreversible progression of tissue infections into severely spreading NSTIs and urge further investigations on the beneficial effect of IVIG-based early phase intervention strategies to prevent the severe effects of this devastating bacterial infection.

OriginalsprogEngelsk
TidsskriftThe Journal of infectious diseases
Vol/bind218
Udgave nummer1
Sider (fra-til)44-52
Antal sider9
ISSN0022-1899
DOI
StatusUdgivet - 5 jun. 2018

ID: 54922341