Pituitary gastrins. Different processing in corticotrophs and melanotrophs

J F Rehfeld, L I Larsson

Abstract

The anterior, intermediate, and neural lobes of porcine pituitaries contain different molecular forms of gastrin. In the anterior lobe, unsulfated large gastrins, component I, and gastrin-34 constitute the main forms. In contrast in the intermediate and neural lobes, gastrin-17, sulfated as well as unsulfated, predominates. Since component I and gastrin-34 are biosynthetic precursors of gastrin-17, the findings indicate that proteolytic processing and amino acid derivatization (sulfation) differs between the lobes. This difference, together with the localization of anterior lobe gastrin in corticotrophs and intermediate lobe gastrin in melanotrophs, emphasizes the close relation and parallelism of the biosynthesis of gastrin and corticotropin peptides.

OriginalsprogEngelsk
TidsskriftJournal of Biological Chemistry
Vol/bind256
Udgave nummer20
Sider (fra-til)10426-9
Antal sider4
ISSN0021-9258
StatusUdgivet - 25 okt. 1981
Udgivet eksterntJa

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