Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pituitary adenylate cyclase-activating peptide: Potential roles in the pathophysiology and complications of cirrhosis

Publikation: Bidrag til tidsskriftReviewForskningpeer review

DOI

  1. Cardiodynamic state is associated with systemic inflammation and fatal acute-on-chronic liver failure

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. HSD17B13 as a promising therapeutic target against chronic liver disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Non-alcoholic fatty liver disease alters expression of genes governing hepatic nitrogen conversion

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Progressive resistance training prevents loss of muscle mass and strength in bile duct-ligated rats

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Current Understanding of the Chronobiology of Cluster Headache and the Role of Sleep in Its Management

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Pathophysiology Behind Cardiopulmonary Complications of Cirrhosis and Portal Hypertension

    Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiFormidling

  3. Statins for cirrhosis: almost ready for clinical application

    Publikation: Bidrag til tidsskriftKommentar/debatForskningpeer review

Vis graf over relationer

Pituitary adenylate cyclase-activating peptide (PACAP) is a ubiquitous neuropeptide with diverse functions throughout the organism. Most abundantly investigated for its role in several neurological disorders as well as in circadian rhythms, other fields of medicine, including cardiology, have recently shown interest in the role of PACAP and its potential as a biomarker. Timely diagnosis and treatment of cirrhosis and its complications is a considerable challenge for health services world-wide and development of new areas of research is warranted. Direct and indirect evidence exists of PACAP involvement in the cascade of pathological events and processes ultimately leading to cirrhosis and its complications, but its exact role remains to be determined. Studies have documented PACAP involvement in immune function, metabolism, local vasoconstriction and -dilatation and systemic vascular decompensation and there is ongoing research of a possible role in liver reperfusion injury. Considering these reports, PACAP could theoretically exude influence on the disease course of cirrhosis through the hypothalamus-pituitary-adrenal-axis, chronic inflammation, fibrogenesis, vasodilation and reduced vascular resistance. The paucity of literature on the specific topic of PACAP and cirrhosis reflects complex mechanisms and difficulty in accurate measurements and sample taking. This does not detract from the need to further characterize and elucidate the role PACAP plays in the underdiagnosed and undertreated condition of cirrhosis.

OriginalsprogEngelsk
TidsskriftLiver international : official journal of the International Association for the Study of the Liver
Vol/bind40
Udgave nummer11
Sider (fra-til)2578-2589
Antal sider12
ISSN1478-3223
DOI
StatusUdgivet - nov. 2020

ID: 60338916