PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer

Jeanette Dupont Jensen; Anne-Vibeke Laenkholm; Ann Knoop; Marianne Ewertz Kvistgaard; Raj Bandaru; Weihua Liu; Wolfgang Hackl; J Carl Barrett; Humphrey Gardner

doi:10.1158/1078-0432.CCR-10-1133

PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer

Jeanette Dupont Jensen, Anne-Vibeke Laenkholm, Ann Knoop, Marianne Ewertz Kvistgaard, Raj Bandaru, Weihua Liu, Wolfgang Hackl, J Carl Barrett, Humphrey Gardner

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181 Citationer (Scopus)

Abstract

PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway. Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In a cohort of patients where both primary and metastatic lesions were available, the objective was to assess changes in PIK3CA mutations. We wished to discern whether selective pressures occur and the influence of PIK3CA mutation on time to recurrence.

Originalsprog	Engelsk
Tidsskrift	Clinical Cancer Research
Vol/bind	17
Udgave nummer	4
Sider (fra-til)	667-77
Antal sider	11
ISSN	1078-0432
DOI	https://doi.org/10.1158/1078-0432.CCR-10-1133
Status	Udgivet - 15 feb. 2011

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10.1158/1078-0432.CCR-10-1133

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title = "PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer",

abstract = "PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway. Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In a cohort of patients where both primary and metastatic lesions were available, the objective was to assess changes in PIK3CA mutations. We wished to discern whether selective pressures occur and the influence of PIK3CA mutation on time to recurrence.",

author = "{Dupont Jensen}, Jeanette and Anne-Vibeke Laenkholm and Ann Knoop and Kvistgaard, {Marianne Ewertz} and Raj Bandaru and Weihua Liu and Wolfgang Hackl and Barrett, {J Carl} and Humphrey Gardner",

note = "{\textcopyright}2010 AACR.",

year = "2011",

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doi = "10.1158/1078-0432.CCR-10-1133",

language = "English",

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TY - JOUR

T1 - PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer

AU - Dupont Jensen, Jeanette

AU - Laenkholm, Anne-Vibeke

AU - Knoop, Ann

AU - Kvistgaard, Marianne Ewertz

AU - Bandaru, Raj

AU - Liu, Weihua

AU - Hackl, Wolfgang

AU - Barrett, J Carl

AU - Gardner, Humphrey

PY - 2011/2/15

Y1 - 2011/2/15

N2 - PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway. Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In a cohort of patients where both primary and metastatic lesions were available, the objective was to assess changes in PIK3CA mutations. We wished to discern whether selective pressures occur and the influence of PIK3CA mutation on time to recurrence.

AB - PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway. Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In a cohort of patients where both primary and metastatic lesions were available, the objective was to assess changes in PIK3CA mutations. We wished to discern whether selective pressures occur and the influence of PIK3CA mutation on time to recurrence.

U2 - 10.1158/1078-0432.CCR-10-1133

DO - 10.1158/1078-0432.CCR-10-1133

M3 - Journal article

C2 - 20940279

SN - 1078-0432

VL - 17

SP - 667

EP - 677

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 4

ER -

PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer

Abstract

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