PIK3CA mutations may be discordant between primary and corresponding metastatic disease in breast cancer

Jeanette Dupont Jensen, Anne-Vibeke Laenkholm, Ann Knoop, Marianne Ewertz Kvistgaard, Raj Bandaru, Weihua Liu, Wolfgang Hackl, J Carl Barrett, Humphrey Gardner

174 Citationer (Scopus)

Abstract

PIK3CA mutations are frequent in breast cancer and activate the PI3K/Akt pathway. Unexpectedly, PIK3CA mutation appears in general to be associated with better outcome. In a cohort of patients where both primary and metastatic lesions were available, the objective was to assess changes in PIK3CA mutations. We wished to discern whether selective pressures occur and the influence of PIK3CA mutation on time to recurrence.
OriginalsprogEngelsk
TidsskriftClinical Cancer Research
Vol/bind17
Udgave nummer4
Sider (fra-til)667-77
Antal sider11
ISSN1078-0432
DOI
StatusUdgivet - 15 feb. 2011

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