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Physiological predictors of weight regain at 1-year follow-up in weight-reduced adults with obesity

Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review


  1. Gut Mucosal Gene Expression and Metabolic Changes After Roux-en-Y Gastric Bypass Surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelpeer review

  • Siren Nymo
  • Silvia R Coutinho
  • Jens F Rehfeld
  • Helen Truby
  • Bård Kulseng
  • Catia Martins
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OBJECTIVE: This study aimed to assess whether changes in resting metabolic rate (RMR), exercise-induced energy expenditure (EIEE), and appetite following weight loss (WL) are associated with weight regain at 1 year.

METHODS: Thirty-six adults with obesity underwent 8 weeks of a very-low-energy diet, followed by 4 weeks of refeeding and a 1-year maintenance program. RMR, EIEE, appetite ratings, and active ghrelin, peptide YY, glucagon-like peptide-1, cholecystokinin, and insulin concentrations were measured at baseline, week 13, and 1 year.

RESULTS: A 17% WL (-20 ± 5 kg [mean ± SD]; range: -11.7 to -32.2 kg; P < 0.001) was achieved at week 13. After 1 year, weight regain was 2.5 ± 9.0 kg (not significant), ranging from -18.2 to 22.5 kg. Both fat mass and fat-free mass were reduced at week 13 (-17.9 ± 4.8 and -2.9 ± 2.7 kg, respectively; P < 0.001), while only loss of fat mass was sustained at 1 year. WL was associated with reduced RMR, EIEE, and fasting/postprandial insulin (all P < 0.001), as well as increased fasting hunger (P < 0.01) and fasting/postprandial active ghrelin (P < 0.001). There were no significant correlations between changes in RMR, EIEE, or appetite with WL and weight regain at 1 year.

CONCLUSIONS: No clear evidence emerged that changes in RMR, EIEE, or appetite following WL can predict weight regain at 1 year, but larger studies are needed to confirm these results.

TidsskriftObesity (Silver Spring, Md.)
Udgave nummer6
Sider (fra-til)925-931
Antal sider7
StatusUdgivet - jun. 2019

Bibliografisk note

© 2019 The Authors. Obesity published by Wiley Periodicals, Inc. on behalf of The Obesity Society (TOS).

ID: 57230980