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Region Hovedstaden - en del af Københavns Universitetshospital
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Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  • Josué Leonardo Castro-Mejía
  • Bekzod Khakimov
  • Lukasz Krych
  • Jacob Bülow
  • Rasmus Bechshoeft
  • Grith Westergaard Højfeldt
  • Kenneth Hudlebusch Mertz
  • Eva Stahl Garne
  • Simon Rønnow Schacht
  • Hajar Fauzan Bin Ahmad
  • Witold Piotr Kot
  • Lars H Hansen
  • Federico Jose Armando Perez-Cueto Eulert
  • Mads Vendelbo Lind
  • Aske Juul Lassen
  • Inge Tetens
  • Tenna Jensen
  • Søren Reitelseder
  • Astrid Pernille Jespersen
  • Lars Holm
  • Søren Balling Engelsen
  • Dennis Sandris Nielsen
Vis graf over relationer
When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.

Keywords: aging; energy and dietary fiber intake; gut microbiota; host metabolome; physical fitness; proinsulin-C-peptide.
OriginalsprogEngelsk
TidsskriftAging Cell
ISSN1474-9718
StatusUdgivet - mar. 2020

ID: 61764075