TY - JOUR
T1 - Physical fitness in community-dwelling older adults is linked to dietary intake, gut microbiota, and metabolomic signatures
AU - Castro-Mejía, Josué Leonardo
AU - Khakimov, Bekzod
AU - Krych, Lukasz
AU - Bülow, Jacob
AU - Bechshoeft, Rasmus
AU - Højfeldt, Grith Westergaard
AU - Mertz, Kenneth Hudlebusch
AU - Garne, Eva Stahl
AU - Schacht, Simon Rønnow
AU - Bin Ahmad, Hajar Fauzan
AU - Kot, Witold Piotr
AU - Hansen, Lars H
AU - Perez-Cueto Eulert, Federico Jose Armando
AU - Lind, Mads Vendelbo
AU - Juul Lassen, Aske
AU - Tetens, Inge
AU - Jensen, Tenna
AU - Reitelseder, Søren
AU - Jespersen, Astrid Pernille
AU - Holm, Lars
AU - Engelsen, Søren Balling
AU - Nielsen, Dennis Sandris
PY - 2020/3
Y1 - 2020/3
N2 - When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.Keywords: aging; energy and dietary fiber intake; gut microbiota; host metabolome; physical fitness; proinsulin-C-peptide.
AB - When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM), and host metabolome in relation to physical fitness of 207 community-dwelling subjects aged +65 years. Stratification on anthropometric/body composition/physical performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to dietary intake, physical activity, GM, and host metabolome patterns. Strikingly, despite a higher energy intake high-fitness subjects were characterized by leaner bodies and lower fasting proinsulin-C-peptide/blood glucose levels in a mechanism likely driven by higher dietary fiber intake, physical activity and increased abundance of Bifidobacteriales and Clostridiales species in GM and associated metabolites (i.e., enterolactone). These factors explained 50.1% of the individual variation in physical fitness. We propose that targeting dietary strategies for modulation of GM and host metabolome interactions may allow establishing therapeutic approaches to delay and possibly revert comorbidities of aging.Keywords: aging; energy and dietary fiber intake; gut microbiota; host metabolome; physical fitness; proinsulin-C-peptide.
M3 - Journal article
SN - 1474-9718
JO - Aging Cell
JF - Aging Cell
ER -