TY - JOUR
T1 - Physical capacity in children and adolescents with newly diagnosed cancer
T2 - A systematic review and meta-analysis
AU - Schmidt-Andersen, Peter
AU - Stage, Anna
AU - Pouplier, Anna
AU - Bastholm, Louise H
AU - Müller, Klaus G
AU - Larsen, Anders
AU - Ness, Kirsten K
AU - Larsen, Hanne B
AU - Christensen, Jan
AU - Fridh, Martin K
N1 - © 2023 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.
PY - 2024/1
Y1 - 2024/1
N2 - OBJECTIVE: To review the body of evidence on cardiorespiratory fitness, muscle strength, and physical performance in children with newly diagnosed cancer, five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Web of Science) were searched on December 19, 2022.METHODS: Thirteen studies, embodying 594 participants within 1 month of cancer diagnosis and 3674 healthy controls were included. Eighteen different outcomes on cardiorespiratory fitness (n = 2), muscle strength (n = 5), physical performance (n = 10), and adverse events (n = 1) were analyzed.RESULTS: Fifteen out of 17 outcomes on physical capacity showed severe impairments compared with healthy controls. Where possible, random-effects meta-analysis was conducted to synthesize the results. No adverse events were reported related to testing.CONCLUSION: Children with cancer have impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the evidence is based on a small number of studies with large clinical heterogeneity, limiting the certainty of evidence.
AB - OBJECTIVE: To review the body of evidence on cardiorespiratory fitness, muscle strength, and physical performance in children with newly diagnosed cancer, five databases (MEDLINE, Embase, CINAHL, CENTRAL, and Web of Science) were searched on December 19, 2022.METHODS: Thirteen studies, embodying 594 participants within 1 month of cancer diagnosis and 3674 healthy controls were included. Eighteen different outcomes on cardiorespiratory fitness (n = 2), muscle strength (n = 5), physical performance (n = 10), and adverse events (n = 1) were analyzed.RESULTS: Fifteen out of 17 outcomes on physical capacity showed severe impairments compared with healthy controls. Where possible, random-effects meta-analysis was conducted to synthesize the results. No adverse events were reported related to testing.CONCLUSION: Children with cancer have impaired cardiorespiratory fitness, muscle strength, and physical performance within the first month after diagnosis. However, the evidence is based on a small number of studies with large clinical heterogeneity, limiting the certainty of evidence.
KW - Adolescent
KW - Cardiorespiratory Fitness
KW - Child
KW - Humans
KW - Muscle Strength/physiology
KW - Neoplasms
KW - Physical Fitness
UR - http://www.scopus.com/inward/record.url?scp=85174708204&partnerID=8YFLogxK
U2 - 10.1002/pbc.30746
DO - 10.1002/pbc.30746
M3 - Review
C2 - 37877893
SN - 1545-5009
VL - 71
JO - Pediatric Blood & Cancer
JF - Pediatric Blood & Cancer
IS - 1
M1 - e30746
ER -