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Physical activity, sedentary behavior and development of preeclampsia in women with preexisting diabetes

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@article{cf419107482e442eb909eae5affa2b7e,
title = "Physical activity, sedentary behavior and development of preeclampsia in women with preexisting diabetes",
abstract = "Aims: To explore the association between physical activity in early pregnancy and development of preeclampsia in women with preexisting diabetes. Methods: In a prospective cohort study of 189 women with preexisting diabetes (110 type 1 and 79 type 2 diabetes), physical activity during pregnancy including sedentary behavior was evaluated with the Pregnancy Physical Activity Questionnaire. Primary outcome was preeclampsia. Secondary outcomes were preterm delivery, large and small for gestational age infants. Results: Women developing preeclampsia (n = 23) had higher diastolic blood pressure in early pregnancy (mean 82 ± 9 SD vs. 77 ± 8, p = 0.004) and were more often nulliparous (91 vs. 52{\%}, p < 0.001) compared with the remaining women (n = 166). Total physical activity in early pregnancy was similar between the groups (median 148 metabolic equivalent of task hours per week (MET-h/week) (interquartile range 118–227) versus 153 (121–205), p = 0.97). In early pregnancy, women developing preeclampsia reported a higher level of sedentary behavior (15 MET-h/week (7–18) versus 7 (4–15); p = 0.04); however, when adjusting for parity, diastolic blood pressure and smoking, the association attenuated (p = 0.13). Total physical activity and sedentary behavior in early pregnancy were not associated with preterm delivery, large or small for gestational age infants. Conclusions: Among women with diabetes, sedentary behavior was reported higher in early pregnancy in women developing preeclampsia compared with the remaining women, while total physical activity was similar. Sedentary behavior was a predictor of preeclampsia in the univariate analysis, but not in the multiple regression analysis, and larger studies are needed to evaluate this possible modifiable risk factor. Trial registration The study was registered at ClinicalTrials.gov (ID: NCT02890836).",
keywords = "Diabetes, Physical activity, Preeclampsia, Pregnancy, Risk factor, Sedentary behavior",
author = "Do, {Nicoline Callesen} and Marianne Vestgaard and Bj{\"o}rg {\'A}sbj{\"o}rnsd{\'o}ttir and Nichum, {Vibeke Ladefoged} and Lene Ringholm and Andersen, {Lise Lotte Torvin} and Jensen, {Dorte M{\o}ller} and Peter Damm and Mathiesen, {Elisabeth Reinhardt}",
year = "2019",
month = "11",
day = "28",
doi = "10.1007/s00592-019-01459-7",
language = "English",
pages = "1--9",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer Italia Srl",

}

RIS

TY - JOUR

T1 - Physical activity, sedentary behavior and development of preeclampsia in women with preexisting diabetes

AU - Do, Nicoline Callesen

AU - Vestgaard, Marianne

AU - Ásbjörnsdóttir, Björg

AU - Nichum, Vibeke Ladefoged

AU - Ringholm, Lene

AU - Andersen, Lise Lotte Torvin

AU - Jensen, Dorte Møller

AU - Damm, Peter

AU - Mathiesen, Elisabeth Reinhardt

PY - 2019/11/28

Y1 - 2019/11/28

N2 - Aims: To explore the association between physical activity in early pregnancy and development of preeclampsia in women with preexisting diabetes. Methods: In a prospective cohort study of 189 women with preexisting diabetes (110 type 1 and 79 type 2 diabetes), physical activity during pregnancy including sedentary behavior was evaluated with the Pregnancy Physical Activity Questionnaire. Primary outcome was preeclampsia. Secondary outcomes were preterm delivery, large and small for gestational age infants. Results: Women developing preeclampsia (n = 23) had higher diastolic blood pressure in early pregnancy (mean 82 ± 9 SD vs. 77 ± 8, p = 0.004) and were more often nulliparous (91 vs. 52%, p < 0.001) compared with the remaining women (n = 166). Total physical activity in early pregnancy was similar between the groups (median 148 metabolic equivalent of task hours per week (MET-h/week) (interquartile range 118–227) versus 153 (121–205), p = 0.97). In early pregnancy, women developing preeclampsia reported a higher level of sedentary behavior (15 MET-h/week (7–18) versus 7 (4–15); p = 0.04); however, when adjusting for parity, diastolic blood pressure and smoking, the association attenuated (p = 0.13). Total physical activity and sedentary behavior in early pregnancy were not associated with preterm delivery, large or small for gestational age infants. Conclusions: Among women with diabetes, sedentary behavior was reported higher in early pregnancy in women developing preeclampsia compared with the remaining women, while total physical activity was similar. Sedentary behavior was a predictor of preeclampsia in the univariate analysis, but not in the multiple regression analysis, and larger studies are needed to evaluate this possible modifiable risk factor. Trial registration The study was registered at ClinicalTrials.gov (ID: NCT02890836).

AB - Aims: To explore the association between physical activity in early pregnancy and development of preeclampsia in women with preexisting diabetes. Methods: In a prospective cohort study of 189 women with preexisting diabetes (110 type 1 and 79 type 2 diabetes), physical activity during pregnancy including sedentary behavior was evaluated with the Pregnancy Physical Activity Questionnaire. Primary outcome was preeclampsia. Secondary outcomes were preterm delivery, large and small for gestational age infants. Results: Women developing preeclampsia (n = 23) had higher diastolic blood pressure in early pregnancy (mean 82 ± 9 SD vs. 77 ± 8, p = 0.004) and were more often nulliparous (91 vs. 52%, p < 0.001) compared with the remaining women (n = 166). Total physical activity in early pregnancy was similar between the groups (median 148 metabolic equivalent of task hours per week (MET-h/week) (interquartile range 118–227) versus 153 (121–205), p = 0.97). In early pregnancy, women developing preeclampsia reported a higher level of sedentary behavior (15 MET-h/week (7–18) versus 7 (4–15); p = 0.04); however, when adjusting for parity, diastolic blood pressure and smoking, the association attenuated (p = 0.13). Total physical activity and sedentary behavior in early pregnancy were not associated with preterm delivery, large or small for gestational age infants. Conclusions: Among women with diabetes, sedentary behavior was reported higher in early pregnancy in women developing preeclampsia compared with the remaining women, while total physical activity was similar. Sedentary behavior was a predictor of preeclampsia in the univariate analysis, but not in the multiple regression analysis, and larger studies are needed to evaluate this possible modifiable risk factor. Trial registration The study was registered at ClinicalTrials.gov (ID: NCT02890836).

KW - Diabetes

KW - Physical activity

KW - Preeclampsia

KW - Pregnancy

KW - Risk factor

KW - Sedentary behavior

U2 - 10.1007/s00592-019-01459-7

DO - 10.1007/s00592-019-01459-7

M3 - Journal article

SP - 1

EP - 9

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

ER -

ID: 58504419