TY - JOUR
T1 - Physical activity and plasma interleukin-6 in humans - Effect of intensity of exercise
AU - Ostrowski, Kenneth
AU - Schjerling, Peter
AU - Pedersen, Bente Klarlund
N1 - Funding Information:
Acknowledgements The excellent technical assistance of Ruth Rousing and Hanne Willumsen is acknowledged. Kenneth Os-trowski was supported by The Copenhagen Muscle Research Centre.
PY - 2000
Y1 - 2000
N2 - The present study included data from three marathon races to investigate the hypothesis that a relationship exists between running intensity and elevated concentrations of interleukin (IL)-6 in plasma. The study included a total of 53 subjects whose mean age was 30.6 [95% confidence interval (CI) 1.4] years, mean body mass 77.7 (95% CI 2.0) kg, mean maximal oxygen uptake (V̇O2max) 59.3 (95%CI 1.4) ml · min-1, · kg-1, and who had participated in the Copenhagen Marathons of 1996, 1997 or 1998, achieving a mean running time of 206 (95%CI 7) min. Running intensity was calculated as running speed divided by V̇O2max. The concentration of IL-6 in plasma peaked immediately after the run. There was a negative correlation between peak IL-6 concentration and running time (r = -0.30, P < 0.05) and a positive correlation between peak IL-6 concentration and running intensity (r = 0.32, P < 0.05). The IL-1 receptor antagonist (IL-1ra) plasma concentration peaked 1.5 h after the run and there was a positive correlation between the peak plasma concentrations of IL-6 and IL-1ra (r = 0.39, P < 0.01). Creatine kinase (CK) plasma concentration peaked on the 1st day after the run, but no association was found between peak concentrations of IL-6 and CK. In conclusion, the results confirmed the hypothesized association between plasma IL-6 concentration and running intensity, but did not confirm the previous finding of a connection between IL-6 plasma concentration and muscle damage.
AB - The present study included data from three marathon races to investigate the hypothesis that a relationship exists between running intensity and elevated concentrations of interleukin (IL)-6 in plasma. The study included a total of 53 subjects whose mean age was 30.6 [95% confidence interval (CI) 1.4] years, mean body mass 77.7 (95% CI 2.0) kg, mean maximal oxygen uptake (V̇O2max) 59.3 (95%CI 1.4) ml · min-1, · kg-1, and who had participated in the Copenhagen Marathons of 1996, 1997 or 1998, achieving a mean running time of 206 (95%CI 7) min. Running intensity was calculated as running speed divided by V̇O2max. The concentration of IL-6 in plasma peaked immediately after the run. There was a negative correlation between peak IL-6 concentration and running time (r = -0.30, P < 0.05) and a positive correlation between peak IL-6 concentration and running intensity (r = 0.32, P < 0.05). The IL-1 receptor antagonist (IL-1ra) plasma concentration peaked 1.5 h after the run and there was a positive correlation between the peak plasma concentrations of IL-6 and IL-1ra (r = 0.39, P < 0.01). Creatine kinase (CK) plasma concentration peaked on the 1st day after the run, but no association was found between peak concentrations of IL-6 and CK. In conclusion, the results confirmed the hypothesized association between plasma IL-6 concentration and running intensity, but did not confirm the previous finding of a connection between IL-6 plasma concentration and muscle damage.
KW - Cytokine
KW - Marathon
KW - Running
UR - http://www.scopus.com/inward/record.url?scp=0034537933&partnerID=8YFLogxK
U2 - 10.1007/s004210000312
DO - 10.1007/s004210000312
M3 - Journal article
C2 - 11192058
AN - SCOPUS:0034537933
SN - 1439-6319
VL - 83
SP - 512
EP - 515
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 6
ER -