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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Photodynamic therapy of necrobiosis lipoidica using methyl aminolevulinate: A retrospective follow-up study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Daylight PDT acts by continuous activation of PpIX

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  2. Pain and stinging associated with pretreatment in photodynamic therapy of actinic keratosis

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  3. Protoporphyrin IX formation after application of methyl aminolevulinate on the face and scalp with and without prior curettage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Intense phototoxic reactions to photodynamic therapy in immunosuppressed renal transplant patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Diagnostic accuracy of optical coherence tomography in actinic keratosis and basal cell carcinoma

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Optimal sunscreen use, during a sun holiday with a very high ultraviolet index, allows vitamin D synthesis without sunburn

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Daylight PDT acts by continuous activation of PpIX

    Publikation: Bidrag til tidsskriftLederForskningpeer review

  3. Serum 25(OH)D levels after oral vitamin D3 supplementation and UVB exposure correlate

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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INTRODUCTION: Necrobiosis lipoidica (NL) is a rare, treatment-resistant, granulomatous skin disease of unknown origin, frequently seen in patients with diabetes.

METHODS: In this retrospective study we evaluated the long-term efficacy of methyl aminolaevulinate-based photodynamic therapy (MAL-PDT), including 80 treatments (70 conventional and 10 daylight PDT), on 65 unselected NL patients treated routinely in our clinic. Superficial curettage, avoiding skin oozing or bleeding, was performed prior to MAL application.

RESULTS: Conventional MAL-PDT had a 100% cure rate (CR) in 64% (45/70) of the treatment series. With daylight PDT we observed a 100% CR in 80% of the treatment series (8/10), an insignificant difference compared to conventional PDT (p = 0.48). The overall cure rate was 66% (53/80). We observed no correlation between CR and gender, age at first PDT treatment, duration of NL prior to PDT treatment, number of NL elements, or diabetes. New lesions faded, whereas old lesions were clearly visible after inactivation of NL.

DISCUSSION: MAL-PDT proved to have full efficacy in 66% of the treatments, with conventional PDT and daylight PDT producing an almost identical result. We observed no correlation between CR and time of follow-up. However, we recommend at least six months to pass before final evaluation of treatment effect.

OriginalsprogEngelsk
TidsskriftPhotodiagnosis and Photodynamic Therapy
Vol/bind22
Sider (fra-til)223-226
Antal sider4
ISSN1572-1000
DOI
StatusUdgivet - jun. 2018

ID: 55208033