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Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency

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  2. Incidence, prevalence and risk factors for hepatitis C in Danish prisons

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  1. Mutant CEBPA directly drives the expression of the targetable tumor-promoting factor CD73 in AML

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  2. Heterozygous loss of Srp72 in mice is not associated with major hematological phenotypes

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  3. Identification of two distinct pathways of human myelopoiesis

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  4. A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis

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  5. The splicing factor RBM25 controls MYC activity in acute myeloid leukemia

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Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions with regulatory proteins that are simultanously recruited and activated to ensure timely gene expression. The transcription factor CCAAT/enhancer binding protein α (C/EBPα) is such a factor and is essential for the development of granulocytic/monocytic cells. The activity of C/EBPα is regulated on several levels including gene expression, alternative translation, protein interactions and posttranslational modifications, such as phosphorylation. In particular, the phosphorylation of serine 248 of the transactivation domain has been shown to be of crucial importance for granulocytic differentiation of 32Dcl3 cells in vitro.
OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind7
Udgave nummer6
Sider (fra-til)e38841
ISSN1932-6203
DOI
StatusUdgivet - 2012

ID: 36840304