Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Phase contrast mapping MRI measurements of global cerebral blood flow across different perfusion states - A direct comparison with 15O-H2O positron emission tomography using a hybrid PET/MR system

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Regional times to equilibria and their impact on semi-quantification of [18F]AV-1451 uptake

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Cerebral metabolism and vascular reactivity during breath-hold and hypoxic challenge in freedivers and healthy controls

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Hybrid PET/MRI imaging in healthy unsedated newborn infants with quantitative rCBF measurements using 15O-water PET

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Effect of hypoxia on BOLD fMRI response and total cerebral blood flow in migraine with aura patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. A visual rating scale for cingulate island sign on 18F-FDG-PET to differentiate dementia with Lewy bodies and Alzheimer's disease

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Diffusion MRI outlined viable tumour volume beats GTV in intra-treatment stratification of outcome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Higher physiological vulnerability to hypoxic exposure with advancing age in the human brain

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Phase-contrast mapping (PCM) magnetic resonance imaging (MRI) provides easy-access non-invasive quantification of global cerebral blood flow (gCBF) but its accuracy in altered perfusion states is not established. We aimed to compare paired PCM MRI and 15O-H2O positron emission tomography (PET) measurements of gCBF in different perfusion states in a single scanning session. Duplicate combined gCBF PCM-MRI and 15O-H2O PET measurements were performed in the resting condition, during hyperventilation and after acetazolamide administration (post-ACZ) using a 3T hybrid PET/MR system. A total of 62 paired gCBF measurements were acquired in 14 healthy young male volunteers. Average gCBF in resting state measured by PCM-MRI and 15O-H2O PET were 58.5 ± 10.7 and 38.6 ± 5.7 mL/100 g/min, respectively, during hyperventilation 33 ± 8.6 and 24.7 ± 5.8 mL/100 g/min, respectively, and post-ACZ 89.6 ± 27.1 and 57.3 ± 9.6 mL/100 g/min, respectively. On average, gCBF measured by PCM-MRI was 49% higher compared to 15O-H2O PET. A strong correlation between the two methods across all states was observed (R2 = 0.72, p < 0.001). Bland-Altman analysis suggested a perfusion dependent relative bias resulting in higher relative difference at higher CBF values. In conclusion, measurements of gCBF by PCM-MRI in healthy volunteers show a strong correlation with 15O-H2O PET, but are associated with a large and non-linear perfusion-dependent difference.

OriginalsprogEngelsk
TidsskriftJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Vol/bind39
Udgave nummer12
Sider (fra-til)2368-2378
ISSN0271-678X
DOI
StatusUdgivet - dec. 2019

ID: 56521771