Abstract
Myocardial ischemia-reperfusion injury is a clinical challenge in interventional cardiology, and at the moment, no pharmacological agent is universally accepted in the prevention. In order to prevent inappropriate clinical trials, a potential pharmacological agent should be proved reproducibly effective in clinically relevant experimental studies before initiation of human studies. The closed-chest porcine model is a promising experimental model of ischemia-reperfusion injury. The purpose of this systematic review was to describe the pharmacological treatments evaluated in the closed-chest porcine model and discuss different aspects of the model for future use. The systematic review was performed according to the PRISMA guidelines.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Cardiovascular Translational Research |
Vol/bind | 7 |
Udgave nummer | 6 |
Sider (fra-til) | 570-80 |
Antal sider | 11 |
ISSN | 1937-5387 |
DOI | |
Status | Udgivet - aug. 2014 |