@article{4cec42ff9b30422b83028a72f3f5f4c5,
title = "Pharmacologic modulation of cerebral metabolic derangement and excitotoxicity in a porcine model of traumatic brain injury and hemorrhagic shock",
abstract = "Cerebral metabolic derangement and excitotoxicity play critical roles in the evolution of traumatic brain injury (TBI). We have shown previously that treatment with large doses of valproic acid (VPA) decreases the size of brain lesion. The goal of this experiment was to determine whether this effect was owing to metabolic modulation.",
keywords = "Adenosine Triphosphate, Animals, Blood Glucose, Brain, Brain Injuries, Calcium, Cerebrovascular Circulation, Disease Models, Animal, Female, Membrane Potential, Mitochondrial, Microdialysis, Neuroprotective Agents, Pyruvate Dehydrogenase Complex, Shock, Hemorrhagic, Swine, Valproic Acid",
author = "Hwabejire, {John O} and Guang Jin and Imam, {Ayesha M} and Michael Duggan and Martin Sillesen and Danielle Deperalta and Jepsen, {Cecilie H} and Jennifer Lu and Yongqing Li and deMoya, {Marc A} and Alam, {Hasan B}",
note = "Copyright {\textcopyright} 2013 Mosby, Inc. All rights reserved.",
year = "2013",
month = aug,
doi = "10.1016/j.surg.2013.04.008",
language = "English",
volume = "154",
pages = "234--43",
journal = "Surgery",
issn = "0039-6060",
publisher = "Mosby, Inc",
number = "2",
}