Pharmacokinetics/Pharmacodynamics of Colistin and Imipenem on Mucoid and Nonmucoid Pseudomonas aeruginosa Biofilms

Hengzhuang Wang, Hong Wu, Oana Ciofu, Zhijun Song, Niels Høiby

168 Citationer (Scopus)

Abstract

The time course of activity of colistin and imipenem against mucoid and nonmucoid Pseudomonas aeruginosa growing in a biofilm showed that compared with those for planktonic bacteria, the kinetics of colistin and imipenem retained the concentration- and time-dependent killing, respectively, but higher doses of antibiotics and longer dosing periods were required for biofilm eradication. Biofilms of mucoid P. aeruginosa were more difficult to eradicate than nonmucoid biofilms.
OriginalsprogEngelsk
TidsskriftAntimicrobial Agents and Chemotherapy
Vol/bind55
Udgave nummer9
Sider (fra-til)4469-74
Antal sider6
ISSN0066-4804
DOI
StatusUdgivet - 1 sep. 2011

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