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Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

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After oral administration, morphine-6-glucuronide (M6G) displays an atypical absorption profile with two peak plasma concentrations. A proposed explanation is that M6G is hydrolysed to morphine in the colon, which is then absorbed and subsequently undergoes metabolism in the liver to morphine-3-glucuronide (M3G) and M6G. The aims of this study were to confirm and elucidate the biphasic absorption profile as well as clarify the conversion of M6G to morphine after a single oral administration of M6G in healthy volunteers.
OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Pharmacology
Vol/bind63
Udgave nummer8
Sider (fra-til)761-7
Antal sider7
ISSN0031-6970
DOI
StatusUdgivet - 1 aug. 2007

ID: 32797334