Abstract
After oral administration, morphine-6-glucuronide (M6G) displays an atypical absorption profile with two peak plasma concentrations. A proposed explanation is that M6G is hydrolysed to morphine in the colon, which is then absorbed and subsequently undergoes metabolism in the liver to morphine-3-glucuronide (M3G) and M6G. The aims of this study were to confirm and elucidate the biphasic absorption profile as well as clarify the conversion of M6G to morphine after a single oral administration of M6G in healthy volunteers.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Clinical Pharmacology |
Vol/bind | 63 |
Udgave nummer | 8 |
Sider (fra-til) | 761-7 |
Antal sider | 7 |
ISSN | 0031-6970 |
DOI | |
Status | Udgivet - 1 aug. 2007 |