Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

P Tfelt-Hansen; L Edvinsson

doi:10.1111/j.1468-2982.2007.01372.x

Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

P Tfelt-Hansen
, L Edvinsson

12 Citationer (Scopus)

Abstract

The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia : an international journal of headache
Vol/bind	27
Udgave nummer	10
Sider (fra-til)	1091-3
Antal sider	3
ISSN	0333-1024
DOI	https://doi.org/10.1111/j.1468-2982.2007.01372.x
Status	Udgivet - okt. 2007

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10.1111/j.1468-2982.2007.01372.x

Citationsformater

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abstract = "The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.",

keywords = "Biological Availability, Cerebral Arteries, Dose-Response Relationship, Drug, Humans, Migraine Disorders, Serotonin Receptor Agonists",

author = "P Tfelt-Hansen and L Edvinsson",

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AU - Edvinsson, L

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AB - The pharmacokinetics of antimigraine drugs zolmitriptan and sumatriptan varied considerably with a fourfold to 10-fold variation in plasma levels. In addition, the pharmacodynamics of triptans as investigated in vitro also varied considerably. In theory, there should probably be a 10-fold variation in doses available, but in clinical practice a fourfold difference in doses will probably cover the needs of most patients.

KW - Biological Availability

KW - Cerebral Arteries

KW - Dose-Response Relationship, Drug

KW - Humans

KW - Migraine Disorders

KW - Serotonin Receptor Agonists

U2 - 10.1111/j.1468-2982.2007.01372.x

DO - 10.1111/j.1468-2982.2007.01372.x

M3 - Journal article

C2 - 17714521

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SP - 1091

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JO - Cephalalgia : an international journal of headache

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ER -

Pharmacokinetic and pharmacodynamic variability as possible causes for different drug responses in migraine. A comment

Abstract

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