PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue

Stine Ringholm; Jakob Grunnet Knudsen; Lotte Leick; Anders Lundgaard; Maja Munk Nielsen; Henriette Pilegaard

doi:10.1371/journal.pone.0064123

PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue

Stine Ringholm, Jakob Grunnet Knudsen, Lotte Leick, Anders Lundgaard, Maja Munk Nielsen, Henriette Pilegaard

67 Citationer (Scopus)

Abstract

The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) PGC-1α determines the basal levels of UCP1 and PRDM16 in WAT and 4) exercise and exercise training regulate UCP1 and PRDM16 expression in WAT in a PGC-1α-dependent manner.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	8
Udgave nummer	5
Sider (fra-til)	e64123
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0064123
Status	Udgivet - 2013

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10.1371/journal.pone.0064123

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abstract = "The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) PGC-1α determines the basal levels of UCP1 and PRDM16 in WAT and 4) exercise and exercise training regulate UCP1 and PRDM16 expression in WAT in a PGC-1α-dependent manner.",

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AU - Ringholm, Stine

AU - Grunnet Knudsen, Jakob

AU - Leick, Lotte

AU - Lundgaard, Anders

AU - Munk Nielsen, Maja

AU - Pilegaard, Henriette

PY - 2013

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AB - The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) PGC-1α determines the basal levels of UCP1 and PRDM16 in WAT and 4) exercise and exercise training regulate UCP1 and PRDM16 expression in WAT in a PGC-1α-dependent manner.

U2 - 10.1371/journal.pone.0064123

DO - 10.1371/journal.pone.0064123

M3 - Journal article

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SN - 1932-6203

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JO - P L o S One

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ER -

PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue

Abstract

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