PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue

Stine Ringholm, Jakob Grunnet Knudsen, Lotte Leick, Anders Lundgaard, Maja Munk Nielsen, Henriette Pilegaard

    64 Citationer (Scopus)

    Abstract

    The aim of the present study was to test the hypotheses that 1) a single exercise bout increases UCP1 mRNA in both inguinal (i)WAT and epididymal (e)WAT, 2) UCP1 expression and responsiveness to exercise are different in iWAT and eWAT, 3) PGC-1α determines the basal levels of UCP1 and PRDM16 in WAT and 4) exercise and exercise training regulate UCP1 and PRDM16 expression in WAT in a PGC-1α-dependent manner.
    OriginalsprogEngelsk
    TidsskriftP L o S One
    Vol/bind8
    Udgave nummer5
    Sider (fra-til)e64123
    ISSN1932-6203
    DOI
    StatusUdgivet - 2013

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